FOCAL CONE ELECTRORETINOGRAMS - AGING AND MACULAR DISEASE
FOCAL CONE ELECTRORETINOGRAMS - AGING AND MACULAR DISEASE
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DOI：
10.1007/bf00154401
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发表时间：
1988-07-01
影响因子：
1.4
通讯作者：
FISH, GE
中科院分区：
文献类型：
--
作者：
BIRCH, DG;FISH, GE
采用3度闪烁刺激，对100只正常眼和134只黄斑病变眼进行了焦锥视网膜电图检查。在用手持刺激器检眼镜直接观察眼底的过程中获得反应。100只正常眼睛的平均中央凹锥体振幅为0.31 μ V，所有振幅的95%大于0.18 μ V。对于从中央凹获得的响应，振幅与年龄之间存在显著的负相关（r = -0.91; p <0.01; p < 0.001），但对于从旁视获得的反应（中央凹和视盘之间的中间，r = -0.53;不显著），则不存在。在已知黄斑病变的眼睛中，平均中心凹锥体振幅与Snellen视力相关。即使在校正了振幅随年龄的正常降低后，在所有视力为20/40或较差的眼中，88/94（94%）的反应显著降低，表明局灶视网膜电图是检测黄斑疾病的敏感试验。
Focal cone electroretinograms were obtained with a 3-degree flickering stimulus from 100 normal eyes and 134 eyes with known macular disease. Responses were obtained during direct visualization of the fundus with a hand-held stimulator-ophthalmoscope. mean foveal cone amplitude for 100 normal eyes was 0.31 .mu.V, with 95% of all ampitudes greater than 0.18 .mu.V. There was a sigificant inverse correlation between amplitude and age for responses obtained from the fovea (r = -0.91; p < 0.01; p < 0.001) but not for responses obtained from the parafovea (midway between fovea and disk, r = -0.53; not significant). In eyes with known maculopathy, mean foveal cone amplitude was correlated with Snellen acuity. Even after correcting for normal decreases in amplitude with age, responses were significantly reduced in 88/94 (94%) of all eyes with 20/40 or poorer acuity, suggesting that the focal electroretinogram is a sensitive test for detecting macular disease.