An update of cancer incidence in the Agricultural Health Study.
An update of cancer incidence in the Agricultural Health Study.
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DOI：
10.1097/jom.0b013e3181f72b7c
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发表时间：
2010-11
影响因子：
3.2
通讯作者：
Freeman LE
中科院分区：
文献类型：
--
作者：
Koutros S;Alavanja MC;Lubin JH;Sandler DP;Hoppin JA;Lynch CF;Knott C;Blair A;Freeman LE
我们的目的是重新评估农业健康研究参与者的癌症发病率。计算标准化发生率比（SIR）和相对标准化比率。私人和商业涂抹者的前列腺癌显著增加，SIR = 1.19（95%可信区间（CI） 1.14, 1.25）和SIR = 1.28（95%可信区间（CI） 1.00, 1.61）。在北卡罗莱纳的私人涂抹者中，观察到过量的唇癌，SIR = 1.97 (95% CI 1.02, 3.44)，多发性骨髓瘤，SIR = 1.42 (95% CI 1.00, 1.95)，爱荷华州配偶的边缘区淋巴瘤，SIR = 2.34 （95% CI 1.21, 4.09）。虽然较低的吸烟率和增加的体力活动可能有助于降低总体癌症发病率，但农业暴露，包括杀虫剂、病毒、细菌、阳光和其他化学物质，可能会增加特定癌症部位的风险。
Our objective is to re-evaluate cancer incidence among Agricultural Health Study participants. Standardized incidence ratios (SIR) and Relative Standardized Ratios were calculated. A significant excess of prostate cancer was seen for private and commercial applicators, SIR = 1.19 (95% Confidence Interval (CI) 1.14, 1.25) and SIR = 1.28 (95% CI 1.00, 1.61), respectively. Excesses were observed for lip cancer, SIR = 1.97 (95% CI 1.02, 3.44), and multiple myeloma, SIR = 1.42 (95% CI 1.00, 1.95) among private applicators from North Carolina and for marginal zone lymphoma among Iowa spouses, SIR = 2.34 (95% CI 1.21, 4.09). While lower rates of smoking and increased physical activity probably contribute to the lower overall cancer incidence, agricultural exposures including pesticides, viruses, bacteria, sunlight, and other chemicals may increase risks for specific cancer sites.