QUANTITATIVE COMPUTED-TOMOGRAPHY FOR PREDICTION OF VERTEBRAL FRACTURE RISK
QUANTITATIVE COMPUTED-TOMOGRAPHY FOR PREDICTION OF VERTEBRAL FRACTURE RISK
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DOI：
10.1016/8756-3282(85)90399-0
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发表时间：
1985-01-01
期刊：
影响因子：
4.1
通讯作者：
ETTINGER, B
中科院分区：
文献类型：
--
作者：
CANN, CE;GENANT, HK;ETTINGER, B
在一项横断面研究中，对94名女性和44名男性骨质疏松症患者的椎体骨小梁矿物质含量和外周皮质骨矿物质进行了测量，并与323名对照受试者的椎体矿物质值进行了比较。在对照组女性中，从20岁到80岁，脊柱骨小梁矿物质随年龄的变化率（通过定量计算机断层扫描测量）平均为每年1.2%，在绝经期表现出加速损失。男性对照组的骨小梁质量平均每年下降0.72%。与年龄匹配的对照组相比，女性放射性平均减少48 mg cm-3（39%），而男性减少66 mg cm-3（50%）。桡骨皮质骨与脊柱骨矿物质相关，男性（r = 0.48）和女性（r = 0.62）。椎体矿物质值高于110 mg cm-3的患者通常不存在椎体压缩性骨折或楔入，而几乎所有值低于65 mg cm-3的患者均发生骨折。定量计算机断层扫描测量椎体松质骨密度有助于确定椎体骨折风险增加的患者。
Vertebral trabecular mineral content and peripheral cortical bone mineral were measured in 94 female and 44 male osteoporotic patients and compared to vertebral mineral values obtained for 323 control subjects in a cross-sectional study. The rate of change of spinal trabecular mineral with age (measured by quantitative computed tomography) in control females averaged 1.2% per year from age 20 to 80, with an accelerated loss demonstated at the menopause. Trabecular bone mass in male controls declined an average 0.72% per year. Female osteoporotics had a mean decrement of 48 mg cm-3 (39%) compared to age-matched controls, whereas males were decreased 66 mg cm-3 (50%). Radial cortical bone was correlated with spinal mineral in osteoporotics for both males (r = 0.48) and females (r = 0.62). Vertebral compression fractures or wedging was generally absent in patients with vertebral mineral values above 110 mg cm-3, whereas almost all patients with values below 65 mg cm-3 had fractures. Quantitative computed tomography for measurement of vertebral trabecular bone mineral density is useful for defining those patients in whom the risk of vertebral fracture is increased.