Low pretreatment serum total testosterone is associated with a high incidence of Gleason score 8-10 disease in prostatectomy specimens: data from ethnic Chinese patients with localized prostate cancer
Low pretreatment serum total testosterone is associated with a high incidence of Gleason score 8-10 disease in prostatectomy specimens: data from ethnic Chinese patients with localized prostate cancer
复制标题
DOI：
10.1111/j.1464-410x.2012.11465.x
复制
发表时间：
2012-12-01
影响因子：
4.5
通讯作者：
Yang, WeiYi
中科院分区：
文献类型：
--
作者：
Dai, Bo;Qu, YuanYuan;Yang, WeiYi
目的探讨临床局限性前列腺癌(PCa)患者术前血清总睾酮水平与预后的关系。对110例前列腺癌根治术患者的临床病理资料进行前瞻性研究。比较两个阈值：阈值1(总睾酮=300 ng/dL)和阈值2(总睾酮=250 ng/dL)。结果术前总睾酮水平中位数为346 ng/dL。21例(19.1%)、67例(60.9%)和22例(20.0%)RP患者的Gleason评分分别为+8。与低度恶性疾病患者相比，高度疾病(Gleason评分=8)患者的术前总睾酮水平显著降低。35例性腺功能减退症患者和75例优生素症患者按阈值1进行比较，未发现明显的相关性。=8个肿瘤在性腺功能减退症患者中更为常见。结论将性腺功能减退的阈值设定在治疗前血清总睾酮的水平
OBJECTIVETo investigate the relationship between preoperative serum total testosterone level and prognostic factors of Chinese patients with clinically localized prostate cancer (PCa).PATIENTS AND METHODSA total of 110 patients with localized PCa, treated by radical prostatectomy (RP), were included in this prospective study.Clinical and pathological data from each patient were collected. Total testosterone was measured on the morning of surgery.Total testosterone levels for each patient were compared using two thresholds: threshold 1 (total testosterone = 300 ng/dL) and threshold 2 (total testosterone = 250 ng/dL).RESULTSThe median preoperative total testosterone level was 346 ng/dL. Gleason scores of = 8 were found in the RP specimens from 21 (19.1%), 67 (60.9%) and 22 (20.0%) patients, respectively.Compared with those with low grade disease, patients with high grade disease (Gleason score >= 8) in RP specimens had a significantly lower preoperative total testosterone.When comparing 35 patients with hypogonadism with 75 patients with eugonadism, classified by threshold 1, no significant relationships were found.When comparing 18 patients with hypogonadism with 92 patients with eugonadism, classified by threshold 2, pathological Gleason score >= 8 tumours were more common in patients with hypogonadism.CONCLUSIONSetting the threshold for hypogonadism at the level of pretreatment serum total testosterone