Spontaneous and methylcholanthrene-enhanced thyroiditis in BUF rats. I. The incidence and severity of the disease, and the genetics of susceptibility.
Spontaneous and methylcholanthrene-enhanced thyroiditis in BUF rats. I. The incidence and severity of the disease, and the genetics of susceptibility.
复制标题
BUF 大鼠自发性和甲基胆蒽增强的甲状腺炎。
作者：
D. Silverman;N. Rose
用甲基胆蒽（MC）处理的处女雌性布法罗品系（BUF）大鼠的淋巴细胞性甲状腺炎发病率高于未处理的BUF大鼠。MC处理大鼠的浸润程度也更大。退休育种雌性BUF大鼠甲状腺炎的发生率接近MC给药大鼠。在BUF和刘易斯（LEW）的大多数F-1杂种中，对MC作用的敏感性未表达，LEW是一种用MC治疗后不发生甲状腺炎的大鼠品系。
Virgin female Buffalo strain (BUF) rats that were treated with methylcholanthrene (MC) had a higher incidence of lymphocytic thyroiditis than untreated BUF rats. The degree of infiltration was also greater in MC-treated rats. The incidence of thyroiditis in retired breeder female BUF rats approached that found in MC-treated rats. The susceptibility to the effect of MC was not expressed in most F-1 hybrids of BUF and Lewis (LEW), a strain of rat that does not develop thyroiditis after treatment with MC.