Relationship of Theiler's murine encephalomyelitis viruses to the cardiovirus genus of picornaviruses.
Relationship of Theiler's murine encephalomyelitis viruses to the cardiovirus genus of picornaviruses.
复制标题
泰勒氏鼠脑脊髓炎病毒与小核糖核酸病毒心脏病毒属的关系。
作者：
Nitayaphan,S;Omilianowski,D;Toth,MM;Parks,GD;Rueckert,RR;Palmenberg,AC;Roos,RP
对Theiler 's鼠脑脊髓炎病毒（TMEV） DA株VPl的序列分析表明，前23个n端氨基酸中有13个与脑心肌炎病毒相应蛋白相同。与脊髓灰质炎病毒1型、2型和3型、柯萨奇病毒B3型、人鼻病毒2型和14型、人甲型肝炎病毒或口蹄疫病毒对应的VPl序列几乎没有相似性。这些结果以及免疫印迹检测到的血清学关系表明，TMEV与心脏病毒的关系比目前归类的肠道病毒更密切。这一新发现的关系为TMEV和心脏病毒之间的重组感染性cDNA研究提供了潜力。
Sequence analysis of VPl in the DA strain of Theiler’s murine encephalomyelitis viruses (TMEV) showed that 13 of the first 23 N-terminal amino acids were identical to those in the corresponding protein of encephalomyocarditis virus. There was little similarity to the corresponding VPl sequences of poliovirus types 1,2 and 3, coxsackievirus B3, human rhinoviruses 2 and 14, human hepatitis A virus or foot-and-mouth disease virus. These results, as well as serological relationships detected by immunoblotting, suggest that the TMEV are more closely related to the cardioviruses than to the enteroviruses with which they are presently classified. This newly recognized relationship suggests potential for recombinant infectious cDNA studies between TMEV and cardioviruses.