Mechanical transmission of lumpy skin disease virus by Rhipicephalus appendiculatus male ticks
Mechanical transmission of lumpy skin disease virus by Rhipicephalus appendiculatus male ticks
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DOI：
10.1017/s0950268812000805
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发表时间：
2013-02-01
影响因子：
4.2
通讯作者：
Oura, C. A. L.
中科院分区：
文献类型：
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作者：
Tuppurainen, E. S. M.;Lubinga, J. C.;Oura, C. A. L.
结节性皮肤病（LSD）是一种经济上重要的牛急性或亚急性病毒性疾病，发生在非洲和中东各地。本研究的目的是调查，如果狼疮皮肤病病毒（LSDV）可以通过非洲棕耳蜱（Rhipicephalus approxulatus Neum.）的机械传播。日本R.用实验感染的病毒血症“供体”牛喂养雄性无尾寒羊。然后将部分喂养的雄性蜱转移到未感染的“受体”奶牛上喂养。受体动物出现病毒血症，显示轻度LSD临床体征并发生血清转化。此外，R.发现无尾蜱雄性通过摄食无可见病变的皮肤传播LSDV，表明蜱摄食部位无病变的病毒血症动物可能是感染源。这是第一次，传播痘病毒的蜱种已被证明，并讨论了这种传播模式的传播LSDV在地方性环境中的重要性。
Lumpy skin disease (LSD) is an economically important, acute or sub-acute, viral disease of cattle that occurs across Africa and in the Middle East. The aim of this study was to investigate if lumpy skin disease virus (LSDV) can be transmitted mechanically by African brown ear ticks (Rhipicephalus appendiculatus Neum.). Laboratory-bred R. appendiculatus males were fed on experimentally infected viraemic 'donor' cattle. Partially fed male ticks were then transferred to feed on an uninfected 'recipient' cow. The recipient animal became viraemic, showed mild clinical signs of LSD and seroconverted. Additionally, R. appendiculatus males were found to transmit LSDV through feeding on skin lacking visible lesions, demonstrating that viraemic animals without lesions at the feeding site of ticks may be a source of infection. This is the first time that transmission of poxviruses by a tick species has been demonstrated and the importance of this mode of transmission in the spread of LSDV in endemic settings is discussed.