Developmental Manipulation-Induced Changes in Cognitive Functioning.
Developmental Manipulation-Induced Changes in Cognitive Functioning.
复制标题
发育操纵引起的认知功能变化。
DOI：
10.1007/7854_2022_389
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发表时间：
2023
影响因子：
--
通讯作者：
Kentner,AmandaC
中科院分区：
文献类型：
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作者：
Kaki,Sahith;DeRosa,Holly;Timmerman,Brian;Brummelte,Susanne;Hunter,RichardG;Kentner,AmandaC
精神分裂症是一种复杂的神经发育障碍，目前尚未确定病因。利用动物对于阐明遗传和环境风险因素在精神分裂症发展中的潜在个体和交叉作用至关重要。在动物中重现精神分裂症患者认知障碍的一种方法是破坏实验室啮齿动物后代的产前或新生儿环境。这种方法可以导致大脑生理学、学习、记忆、注意力和感觉运动领域的一致扰动。利用此类动物模型的实验设计极大地提高了对精神分裂症病因学和症状学基础的生物学机制的理解，尽管还有更多的东西有待发现。研究和领域标准 (RDoC) 的实施对于采取更全面的方法来确定精神分裂症患者异常行为背后的神经机制至关重要，方法是通过针对机制而不是关注症状的跨诊断方法。在这里，我们使用 RDoC 视角方法描述了几种精神分裂症的神经发育动物模型。动物模型的实施与 RDoC 框架相结合，将促进精神分裂症研究，从而产生更有针对性、可能更有效的治疗干预措施，从而带来更好的患者治疗结果。
Schizophrenia is a complex neurodevelopmental disorder with as-yet no identified cause. The use of animals has been critical to teasing apart the potential individual and intersecting roles of genetic and environmental risk factors in the development of schizophrenia. One way to recreate in animals the cognitive impairments seen in people with schizophrenia is to disrupt the prenatal or neonatal environment of laboratory rodent offspring. This approach can result in congruent perturbations in brain physiology, learning, memory, attention, and sensorimotor domains. Experimental designs utilizing such animal models have led to a greatly improved understanding of the biological mechanisms that could underlie the etiology and symptomology of schizophrenia, although there is still more to be discovered. The implementation of the Research and Domain Criterion (RDoC) has been critical in taking a more comprehensive approach to determining neural mechanisms underlying abnormal behavior in people with schizophrenia through its transdiagnostic approach toward targeting mechanisms rather than focusing on symptoms. Here, we describe several neurodevelopmental animal models of schizophrenia using an RDoC perspective approach. The implementation of animal models, combined with an RDoC framework, will bolster schizophrenia research leading to more targeted and likely effective therapeutic interventions resulting in better patient outcomes.