The evaluation of neutrophil-lymphocyte ratio in children with asthma
The evaluation of neutrophil-lymphocyte ratio in children with asthma
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DOI：
10.1016/j.aller.2015.09.005
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发表时间：
2016-07-01
影响因子：
1.8
通讯作者：
Mutlu, R. G. Yesiltepe
中科院分区：
文献类型：
--
作者：
Dogru, M.;Mutlu, R. G. Yesiltepe
背景：中性粒细胞-淋巴细胞比率(NLR)是一种用于评价全身炎症反应的指标。目前对哮喘患者中性粒细胞/淋巴细胞比率知之甚少。在本研究中，我们旨在评估哮喘儿童的NLR，并评估其与临床参数的关系。方法：469名在本院接受随访的哮喘儿童被纳入研究。对照组包括170名没有过敏性疾病(如哮喘、过敏性鼻炎、湿疹)或感染的儿童。所有患者都使用相同的抗原进行皮肤点刺试验。检测免疫球蛋白E水平和全血计数。结果：不同性别、年龄组间比较无差异。研究组平均NLR为2.07+/-1.41，对照组为1.77+/-1.71。差异有统计学意义(p=0.043)。NLR与性别、家族特应性、吸烟暴露、对过敏原的敏感性之间没有统计学差异(p>；0.05)。平均中性粒细胞受体与住院次数呈弱正相关(r：0.216；p：0.012)，嗜酸性粒细胞百分率与中性粒细胞受体呈弱负相关(r：-0.195；p：0.001)。我们认为NLR可以用来评价哮喘患者的全身炎症反应。然而，还需要进一步的研究来评估哮喘患者的呼吸道和全身炎症以及NLR。(C)2015年东南亚国家经济共同体。由Elsevier Espana，S.L.U出版。版权所有。
Background: Neutrophil-lymphocyte ratio (NLR) is a test used to evaluate the systemic inflammation. There is little knowledge about the neutrophil-lymphocyte ratio in asthmatics. In our study, we aimed to evaluate NLR and to assess its relationship with clinical parameters in children with asthma.Methods: Four hundred and sixty-nine children diagnosed with asthma and followed in our hospital were included in the study. The control group included 170 children with no evidence of allergic disease (i.e. asthma, allergic rhinitis, eczema) or infection. Skin prick tests were performed using the same antigens for all patients. The immunoglobulin E levels and complete blood count were measured.Results: There was no difference between the groups with regard to gender and age. Mean NLR was 2.07 +/- 1.41 in the study group and 1.77 +/- 1.71 in the control group. The difference was statistically significant (p = 0.043). There was no statistically significant difference between NLR and gender, familial atopy, exposure to smoke, sensitivity to allergens (p>0.05). While mean NLR was weakly positively correlated with number of hospitalisations (r: 0.216; p: 0.012), the percentage of eosinophils was weakly negatively correlated with NLR (r: -0.195; p: 0.001).Conclusion: Mean NLR is higher in asthmatic children compared to control group. We think that NLR could be used for the evaluation of systemic inflammation in asthmatic patients. However, further studies are needed to assess airway and systemic inflammation as well as NLR in patients with asthma. (C) 2015 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.