PROGRESSIVE DETERMINATION DURING FORMATION OF THE ANTEROPOSTERIOR AXIS IN XENOPUS-LAEVIS
PROGRESSIVE DETERMINATION DURING FORMATION OF THE ANTEROPOSTERIOR AXIS IN XENOPUS-LAEVIS
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DOI：
10.1016/0092-8674(89)90413-3
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发表时间：
1989-07-14
期刊：
影响因子：
64.5
通讯作者：
WEINTRAUB, H
中科院分区：
文献类型：
--
作者：
SIVE, HL;HATTORI, K;WEINTRAUB, H
水泥腺是青蛙胚胎头部的外胚层器官，位于任何神经组织的前面。通过特异性 RNA 表达分析，骨水泥腺与神经组织一样，是由背侧中胚层诱导的。有趣的是，具有最高水泥腺诱导潜力的中胚层位于注定形成该器官的外胚层后面，表明其诱导发生在距诱导物源一定距离处。水泥腺诱导首先发生在原肠胚早期。然而，大多数最初诱导的细胞并没有形成成熟的水泥腺，而是形成了神经板的一部分。这种命运的改变可以在体外重建。这些结果表明，前后轴的一部分的确定是逐渐发生的，其中未来的神经外胚层首先被诱导为水泥腺样状态。随着原肠胚形成的进行，中胚层的进一步诱导可能会推翻这种状态，这种状态仅持续在胚胎的最前部。
The cement gland is an ectodermal organ in the head of frog embryos, lying anterior to any neural tissue. As analyzed by specific RNA expression, cement gland, like neural tissue, was induced by the dorsal mesoderm. Interestingly, mesoderm with the highest cement gland-inducing potential lay posterior to the ectoderm fated to form this organ, indicating that its induction occurred at a distance from the inducer source. Cement gland induction first occurred during early gastrulation. However, most initially induced cells did not contribute to the mature cement gland, but instead formed part of the neural plate. This change in fate could be reconstituted in vitro. These results suggest that determination of part of the anteroposterior axis occurs progressively, where future neural ectoderm is first induced to a cement gland-like state. As gastrulation proceeds, further induction by mesoderm may override this state, which persists only in the extreme anterior of the embryo.