Mammary tumorigenesis and metastasis in transgenic mice.
Mammary tumorigenesis and metastasis in transgenic mice.
复制标题
转基因小鼠乳腺肿瘤的发生和转移。
DOI：
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发表时间：
1994
影响因子：
14.5
通讯作者：
Muller Wj
中科院分区：
文献类型：
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作者：
M. Webster;Muller Wj
转基因小鼠已成为评估乳腺上皮癌基因转化潜力的重要模型系统。转基因小鼠中癌基因的乳腺特异性表达导致了从良性上皮增生到转移性乳腺肿瘤的各种表型的诱导。在大多数这些转基因模型中，肿瘤的诱导是一个多步骤的过程，其中转基因表达虽然是必需的，但不足以将原代乳腺上皮细胞转化为转化的表型。虽然许多这些协作遗传事件的身份是模糊的，但已经应用了几种方法，可能会揭示它们的性质。在少数特殊的转基因株系中，肿瘤进展可能非常迅速，这表明如果需要额外的遗传事件，它们会非常频繁地发生。最近的遗传和生物化学特性，这些菌株提供了深入了解的分子机制，可能是这些转基因菌株所表现出的复杂的表型特征。
The transgenic mouse has emerged as an important model system to assess the transforming potential of oncogenes in the mammary epithelium. Mammary gland-specific expression of oncogenes in transgenic mice has resulted in the induction of a variety of phenotypes ranging from benign epithelial hyperplasias to metastatic mammary tumors. The induction of tumors in most of these transgenic models is a multi-step process where transgene expression, although required, is not sufficient for conversion of the primary mammary epithelial cell to the transformed phenotype. While the identity of many of these collaborating genetic events is obscure, several approaches have been applied with might shed light on their nature. In a few exceptional transgenic strains, tumor progression can occur very rapidly suggesting that, if additional genetic events are required, they occur very frequently. Recent genetic and biochemical characterization of these strains offers insight into the molecular mechanisms that may underlie the complex phenotypic features exhibited by these transgenic strains.