Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era
Structure-activity relationship homology (SARAH): a conceptual framework for drug discovery in the genomic era
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DOI：
10.1016/s1074-5521(99)80013-1
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发表时间：
1999-01-01
影响因子：
--
通讯作者：
Frye, SV
中科院分区：
文献类型：
--
作者：
Frye, SV
Extension of the traditional pharmacological approach of protein target classification to whole target systems has the potential to relate elements of protein sequence to the structure-activity relationship (SAR) of small molecules that can modulate protein action. Grouping potential drug discovery targets into families based on the relatedness of their SAR provides a means to translate the information from genome-sequencing efforts into knowledge that will aid in the discovery of drugs.
