Dipping in Ambulatory Blood Pressure Monitoring Correlates With Overnight Urinary Excretion of Catecholamines and Sodium
Dipping in Ambulatory Blood Pressure Monitoring Correlates With Overnight Urinary Excretion of Catecholamines and Sodium
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DOI：
10.1111/jch.12791
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发表时间：
2016-09-01
影响因子：
2.8
通讯作者：
Eisenhofer, Graeme
中科院分区：
文献类型：
--
作者：
Daerr, Roland;Bursztyn, Michael;Eisenhofer, Graeme
非下降性血压（BP）与发病率和死亡率增加有关。本研究探讨24小时动态血压监测（ABPM）下降与清醒和睡眠时尿去甲肾上腺素（NE）和肾上腺素（EPI）的关系，以及尿NE和肾上腺素（EPI）与尿钠（UNa）的关系。本研究包括50名非勺型和65名勺型。收集的数据包括年龄、性别、体重指数、高血压病史、当前抗高血压治疗、ABPM数据以及NE、EPI和UNa值。以收缩压昼夜比值（NDR）为因变量的分层多元回归分析显示，尿NE和EPI的NDR复合项是下降的显著预测因子。结果还表明，不同的作用，NE和EPI在昼夜尿钠排泄的勺型和非勺型。这些结果表明，交感神经系统参与了昼夜血压变化和尿钠排泄的调节。
Nondipping blood pressure (BP) is associated with increased morbidity and mortality. This study examines the relationship of dipping in 24-hour ambulatory BP monitoring (ABPM) with awake and sleeping urinary norepinephrine (NE) and epinephrine (EPI), and that of urinary NE and EPI with urinary sodium (UNa). Fifty nondippers and 65 dippers were included in the present study. Collected data included age, sex, body mass index, history of hypertension, current antihypertensive treatment, ABPM data, and NE, EPI, and UNa values. Hierarchical multiple regression analysis with the night-to-day ratio (NDR) of systolic BP as a dependent variable showed that the composite term of the NDRs of urinary NE and EPI was a significant predictor for dipping. Results also show a differential role of NE and EPI in circadian UNa excretion in dippers and nondippers. These results indicate that the sympathetic nervous system is involved in the regulation of circadian BP variations and UNa excretion.