Breed differences in humoral and cellular responses of lambs to experimental infection with the gastrointestinal nematode Teladorsagia circumcincta
Breed differences in humoral and cellular responses of lambs to experimental infection with the gastrointestinal nematode Teladorsagia circumcincta
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DOI：
10.1186/s13567-014-0137-0
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发表时间：
2015-02-17
影响因子：
4.4
通讯作者：
Good, Barbara
中科院分区：
文献类型：
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作者：
Ahmed, Albin Mostaque;Sebastiano, Simone Rocco;Good, Barbara
虽然与萨福克羔羊相比，特塞尔羔羊对胃肠道线虫环切腹弧菌感染的抵抗力增强，但潜在的耐药机制仍不清楚。本研究的目的是比较特塞尔羔羊和萨福克羔羊在一次包皮环切虫实验感染后的寄生虫学、体液和细胞反应。无胃肠道线虫（但不是初生）的羔羊接受单次口服3 × 10(4)具感染性的环皮绦虫幼虫。检查的变量包括蠕虫负荷、黏膜和血清IgA、皱胃肥大细胞和嗜酸性粒细胞、血液学参数和血浆胃蛋白酶原。与萨福克羔羊相比，特塞尔羔羊在第14天的蠕虫负荷显著降低，血浆胃蛋白酶原浓度也显著降低，粘膜IgA对感染的反应发生得更早。研究结果表明，Texel中较早的局部IgA反应有助于该品种的耐药特征，而萨福克羔羊血浆胃蛋白酶原水平的增加意味着线虫感染引起的更大的皱胃组织损伤。
While Texel lambs have increased resistance to infection with the gastrointestinal nematode Teladorsagia circumcincta compared to Suffolk lambs, the underlying resistance mechanisms are still unknown. The aim of this study was to compare parasitological, humoral and cellular responses of Texel and Suffolk lambs over time following a single experimental infection with T. circumcincta. Gastrointestinal nematode free (but not naive) lambs received a single oral dose of 3 x 10(4) infective T. circumcincta larvae. The variables examined included worm burden, mucosal and serum IgA, abomasal mast cells and eosinophils, haematological parameters and plasma pepsinogen. Texel lambs had significantly lower worm burden on day 14 and lower plasma pepsinogen concentration from day 14 onwards than Suffolks and their response in mucosal IgA to infection occurred earlier. The results from the study suggest that an earlier local IgA response in the Texel contributes to the resistant characteristics of the breed, while the increased level of plasma pepsinogen in the Suffolk lambs implies greater abomasal tissue damage arising from the nematode infection.