Focal multiple sclerosis lesions abound in 'normal appearing white matter'
Focal multiple sclerosis lesions abound in 'normal appearing white matter'
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DOI：
10.1177/1352458511415305
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发表时间：
2011-11-01
影响因子：
5.8
通讯作者：
Evangelou, Nikos
中科院分区：
文献类型：
--
作者：
Mistry, Niraj;Tallantyre, Emma C.;Evangelou, Nikos
背景资料：多发性硬化症（MS）中的“正常外观白色物质”（NAWM）使用定量磁共振（MR）技术被认为是异常的。目的：探讨高场强和超高场强T（1）加权磁化预处理的快速采集梯度回波（MPH）MRI是否能检测到MS白色病变，以及高场强T（2）加权液体衰减反转恢复（FLAIR）MRI是否能检测到MS白质病变。方法：14例MS患者行MRI扫描，采用3TFLAIR、MP3和7 T MP3序列。独立观察者在3T FLAIR和（7T和3T）MPT图像上识别病变。每一个单独的病灶的检测，然后比较每一个图像type.Results：我们确定了共812个白色病变的3TFLAIR。使用3T MP30，检测到186个额外的病灶，而使用3T FLAIR未检测到。使用7 T MPRAGE，检测到了231个使用3 T FLAIR未检测到的额外病变。结论：使用3 T和7 T MPRAGE的MRI能够使用3 T FLAIR检测定义为NAWM的区域中的MS病变。局灶性MS病变导致已知存在于NAWM中的异常。
Background: The 'normal appearing white matter' (NAWM) in multiple sclerosis (MS) is known to be abnormal using quantitative magnetic resonance (MR) techniques. The aetiology of the changes in NAWM remains debatable.Objective: To investigate whether high-field and ultra high-field T(1)-weighted magnetization prepared rapid acquisition gradient echo (MPRAGE) MRI enables detection of MS white matter lesions in areas defined as NAWM using high-field T(2)-weighted fluid attenuation inversion recovery (FLAIR) MRI; that is, to ascertain whether undetected lesions are likely contributors to the burden of abnormality in similarly defined NAWM.Methods: Fourteen MS patients underwent MRI scans using 3T FLAIR and MPRAGE and 7 Tesla (7T) MPRAGE sequences. Independent observers identified lesions on 3T FLAIR and (7T and 3T) MPRAGE images. The detection of every individual lesion was then compared for each image type.Results: We identified a total of 812 white matter lesions on 3T FLAIR. Using 3T MPRAGE, 186 additional lesions were detected that were not detected using 3T FLAIR. Using 7T MPRAGE, 231 additional lesions were detected that were not detected using 3T FLAIR.Conclusions: MRI with 3T and 7T MPRAGE enables detection of MS lesions in areas defined as NAWM using 3T FLAIR. Focal MS lesions contribute to the abnormalities known to exist in the NAWM.