MALIGNANT-LYMPHOMA OF THE LIVER - REPORT OF 5 CASES AND REVIEW OF THE LITERATURE
MALIGNANT-LYMPHOMA OF THE LIVER - REPORT OF 5 CASES AND REVIEW OF THE LITERATURE
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DOI：
10.1007/bf01300294
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发表时间：
1992-07-01
影响因子：
3.1
通讯作者：
WAKATA, Y
中科院分区：
文献类型：
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作者：
OHSAWA, M;AOZASA, K;WAKATA, Y
原发性肝淋巴瘤是一种罕见的疾病。我们在此报告五个病例，并总结我们自己和西方国家和日本报告的病例的临床和病理特征。案件总数为68起。患者年龄范围为7 - 87岁（中位数55岁），男女比例为3.1：1。44%的日本病例和9.6%的西方病例在肝淋巴瘤发作前出现慢性肝炎或肝硬化。大体上，肝脏被单个肿块（60%）、多个肿块（35%）或弥漫性病变（5%）所占据，但无结节形成。组织学上所有病例均为非何杰金氏淋巴瘤，以弥漫性大细胞型最常见。滤泡性淋巴瘤3例（4.4%）。免疫组化B细胞型约占80%。随访结果显示，早期发现肝淋巴瘤预后较好。
Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic hepatitis or cirrhosis before onset of hepatic lymphoma was noted in 44% of Japanese cases and 9.6% of Western cases. Macroscopically, the liver was occupied by solitary mass (60%), multiple masses (35%), or a diffuse lesion without nodule formation (5%). Histologically all cases were non-Hodgkin's lymphoma with the diffuse large cell type being most common. Three cases (4.4%) were follicular lymphoma. Immunohistochemically about 80% of the cases were B-cell type. Follow-up study showed that hepatic lymphoma had a relatively favorable prognosis when early detection of the disease was possible.