HYPOPHAGIA, HYPODIPSIA, AND HYPOACTIVITY FOLLOWING ELECTROLYTIC LESIONS IN DORSOMEDIAL HYPOTHALAMIC NUCLEI OF MATURE RATS OF BOTH SEXES
HYPOPHAGIA, HYPODIPSIA, AND HYPOACTIVITY FOLLOWING ELECTROLYTIC LESIONS IN DORSOMEDIAL HYPOTHALAMIC NUCLEI OF MATURE RATS OF BOTH SEXES
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DOI：
10.1007/bf01244724
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发表时间：
1972-01-01
影响因子：
3.3
通讯作者：
BERNARDIS, LL
中科院分区：
文献类型：
--
作者：
BERNARDIS, LL
电解损毁雌性和雄性成年大鼠双侧下丘脑背内侧核，可导致吞咽功能减退、吞咽减少和自发跑步活动减少。后者与脂肪沉积增加无关。静息耗氧量在两性中都有所减少，但只有男性显著减少。雌雄大鼠甲状腺重量均正常，但雌性大鼠卵巢和肾上腺较轻，雄性病变大鼠垂体较轻。数据表明，下丘脑背内侧核参与了下丘脑控制食物摄取、水摄取和自发活动的机制，不仅如先前证明的那样，在断奶大鼠中也是如此，在成熟大鼠中也是如此。
Electrolytic bilateral lesions of the dorsomedial hypothalamic nucleus of both female and male mature rats resulted in hypophagia, hypodipsia and decreased spontaneous running activity. The latter is not associated with increased fat deposition. Resting oxygen consumption was reduced in both sexes, but significantly only in the males. Thyroid weight was normal in both sexes but ovaries and adrenals were lighter in the females and the pituitary was lighter in the male rats with lesions. The data show that the dorsomedial hypothalamic nucleus is involved in hypothalamic mechanisms controlling food intake, water intake and spontaneous activity not only in the weanling rat as previously demonstrated, but in the mature rat as well.