VEP vernier, VEP grating, and behavioral grating acuity in patients with cortical visual impairment.
VEP vernier, VEP grating, and behavioral grating acuity in patients with cortical visual impairment.
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DOI：
10.1097/opx.0b013e3181a59d2a
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发表时间：
2009-06
期刊：
影响因子：
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通讯作者：
Haegerstrom-Portnoy G
中科院分区：
文献类型：
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作者：
Watson T;Orel-Bixler D;Haegerstrom-Portnoy G
皮质性视力障碍（CVI）是双侧视力障碍的主要原因。由于许多CVI患者不能进行视型测试，他们的视敏度通常用光栅刺激测量，使用优先视（PL）测试或视觉诱发电位（VEP）记录。本研究的目的是确定CVI患者VEP游标锐度、VEP光栅锐度和行为光栅锐度之间的关系。对29例CVI患者进行扫描VEP游标视敏度、扫描VEP光栅视敏度和行为光栅视敏度测量（用PL卡测量）。患者年龄3.2 ~ 22.7岁（平均12.3岁，标准差5.3岁）。由于游标敏锐度和光栅敏锐度的测量单位不同，因此将测量结果表示为对数亏缺（法向分别为30℃/度和0.5弧分）。VEP光栅的视敏度损失与VEP游标的视敏度损失呈显著相关（r=0.70），斜率为1.31，说明游标的视敏度平均比VEP光栅的视敏度差0.2 log单位。行为光栅的锐度损失与VEP光栅的锐度损失也显著相关（r=0.64），斜率为1.55，表明行为光栅的锐度损失更大（约0.3 log单位）。VEP游标视力下降与行为光栅视力下降呈显著相关（r=0.66），斜率为0.85，说明行为视力和VEP游标视力下降幅度相近。对VEP游标灵敏度法和行为灵敏度法进行的Bland-Altman比较显示出一个平坦的斜率（0.30），表明这两种测量方法在整个视敏度水平范围内产生相似的视敏度测量值。在CVI患者中，VEP游标敏锐度比VEP光栅敏锐度表现出更大的缺陷，并且与光栅敏锐度的行为测量更相似。
Cortical visual impairment (CVI) is a leading cause of bilateral vision impairment. Since many patients with CVI cannot perform an optotype test, their acuity is often measured with a grating stimulus using a preferential looking (PL) test or the visual evoked potential (VEP) recording. The purpose of this study is to determine the relationship between VEP vernier acuity, VEP grating acuity and behavioral grating acuity in patients with CVI. Sweep VEP vernier acuity, sweep VEP grating acuity, and behavioral grating acuity (measured with PL cards) were measured in 29 patients with CVI. The patients ranged in age from 3.2 to 22.7 years (mean: 12.3; SD: 5.3). Because the measures of vernier acuity and grating acuity have different units, the results were expressed as the log deficit (with normal being 30 c/deg and 0.5 arc min respectively). VEP grating acuity loss and VEP vernier acuity loss were significantly related (r=0.70) with a slope of 1.31, indicating that indicating that on average, vernier acuity showed a 0.2 log unit deficit compared to VEP grating acuity. Behavioral grating acuity loss and VEP grating acuity loss were also significantly related (r=0.64) with a slope of 1.55, indicating that behavioral acuity was more reduced (by approximately 0.3 log unit). VEP vernier acuity loss and behavioral grating acuity loss were significantly related (r=0.66) with a slope of 0.85, indicating that behavioral acuity and VEP vernier acuity showed a similar magnitude of reduction. A Bland-Altman comparison between the VEP vernier acuity method and the behavioral acuity method showed a flat slope (0.30), indicating that the two measures produce similar visual acuity measures across the range of acuity levels. In patients with CVI, VEP vernier acuity showed greater deficits than VEP grating acuity and was more similar to the behavioral measures of grating acuity.