Optic neuritis as onset manifestation of multiple sclerosis - A nationwide, long-term survey
Optic neuritis as onset manifestation of multiple sclerosis - A nationwide, long-term survey
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DOI：
10.1212/wnl.53.3.473
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发表时间：
1999-08-11
期刊：
影响因子：
9.9
通讯作者：
Petersen, HC
中科院分区：
文献类型：
--
作者：
Sorensen, TL;Frederiksen, JL;Petersen, HC
目的：为了确定生存的视神经炎（ON）MS的发病表现的预测价值。方法：我们使用的数据来自丹麦多发性硬化症登记处，其中包括几乎所有的MS诊断患者在丹麦。从1949年到1990年，登记了7,548名符合MS标准化诊断标准的MS患者。结果：6，923例患者的MS发病表现已知，1，282例患者（19%）为ON。这些患者的平均发病年龄为31.1岁，而具有其他或未知MS发作表现（非ON）的患者为34.8岁（p < 0.001）。从MS的首次已知表现到MS的最终诊断的平均延迟为6.1年（ON）和4.2年（非ON）。中位生存期（从ON开始的时间）男性为30年（与之匹配的一般男性人群为41年），女性为40年（与之匹配的一般男性人群为47年）。在每个性别的人中，MS发病时的超额死亡率随着年龄的增长而增加。女性的超额死亡率在以ON为发病表现的患者与以其他或未知MS发病表现的患者之间存在显著差异（8.3 vs 13.0）。在以ON作为MS的发病表现的患者中，男性的超额死亡率（14.0）显著高于女性（8.3）。结论：以ON为首发表现的MS患者，仅女性患者的死亡率高于男性患者，生存预后较好。
Objective: To determine the predictive value on survival of optic neuritis (ON) as onset manifestation of MS. Methods: We used data obtained from the Danish Multiple Sclerosis Registry, which includes virtually all patients diagnosed with MS in Denmark. From 1949 to 1990, 7,548 unselected patients fulfilling standardized diagnostic criteria of MS were registered. Results: The onset manifestation of MS was known in 6,923 patients, and was ON in 1,282 patients (19%). The mean age at onset was 31.1 years for these patients compared with 34.8 years for patients with another or unknown onset manifestation of MS (non-ON) (p < 0.001). The mean delay from the first known manifestation of MS to the final diagnosis of MS was 6.1 years (ON) and 4.2 years (non-ON). The median survival, time from onset of ON was 30 years in men (compared with 41 years in the matched general male population) and 40 years in women (versus 47 years). The excess death rate increased with age at onset of MS in people of each sex. Excess death rate for women differed significantly between patients with ON as onset manifestation and patients with another or unknown onset manifestation of MS (8.3 versus 13.0). In patients with ON as onset manifestation of MS, the excess death rate was significantly higher in men (14.0) than in women (8.3). Conclusion: ON as onset manifestation of MS indicates a more favorable prognosis of survival of MS judged by excess death rate only in women.