Restraint stress affects hippocampal cell proliferation differently in rats and mice
Restraint stress affects hippocampal cell proliferation differently in rats and mice
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DOI：
10.1016/j.neulet.2004.04.096
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发表时间：
2004-09-16
影响因子：
2.5
通讯作者：
Rusak, B
中科院分区：
文献类型：
--
作者：
Bain, MJ;Dwyer, SM;Rusak, B
颗粒细胞神经发生发生在哺乳动物海马齿状回的整个成年生活，并掺入溴脱氧尿苷（BrdU）到DNA中可以作为细胞分裂与这样的神经发生相关的标记。我们研究了应激物（抑制）对Sprague-Dawley大鼠和C57 BL/6 J小鼠海马细胞增殖的影响。在束缚应激后立即处死动物，并制备其脑用于免疫组织化学研究。约束压力引起类似的显着增加c-Fos免疫反应性细胞在下丘脑室旁核的两个物种，表明所经历的压力是相似的。约束程序也导致大鼠齿状回BrdU标记显着减少，如前所述，但在小鼠相同区域显着增加。海马细胞增殖似乎对这些物种的束缚应激反应不同。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Granule cell neurogenesis occurs in the dentate gyrus of the mammalian hippocampus throughout adult life, and incorporation of bromodeoxyuridine (BrdU) into DNA can serve as a marker of cell division associated with such neurogenesis. We examined the effects of a stressor Q h of restraint) on hippocampal cell proliferation in Sprague-Dawley rats and C57BL/6J mice. Animals were killed immediately following restraint stress and their brains were prepared for immunohistochemical studies. Restraint stress caused similar significant increases in c-Fos immunoreactivity among cells in the hypothalamic paraventricular nucleus of both species, indicating that the stress experienced was similar. The restraint procedure also caused a significant decrease in BrdU labeling in the dentate gyrus of rats, as previously reported, but a significant increase in the same region in mice. Hippocampal cell proliferation appears to respond differently to restraint stress in these species. (C) 2004 Elsevier Ireland Ltd. All rights reserved.