Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age.
Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age.
复制标题
随着年龄的增长，大鼠门静脉周围肝细胞中γ-谷氨酰转肽酶活性重新升高。
DOI：
10.20772/cancersci1959.71.3_362
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
K. Sato
中科院分区：
文献类型：
--
作者：
T. Kitagawa;F. Imai;K. Sato
通过组织化学和生物化学研究了大鼠肝脏中γ-谷氨酰转肽酶（γ-GTP）水平随年龄的变化。在新生大鼠肝脏的整个肝小叶中都观察到高酶活性，其中在门静脉周围区域占优势。这种酶活性几乎从年轻人的肝细胞中完全消失。然而，30周龄后，门静脉周围肝细胞中的酶活性逐渐重新升高，达到与新生儿肝脏相似的水平。大鼠肝细胞中 γ-GTP 活性的表达不仅与新生儿事件有关，而且与衰老有关。
Changes in the level of gamma-glutamyl transpeptidase (gamma-GTP) in the rat liver with age were studied histochemically and biochemically. A high enzyme activity was seen throughout the hepatic lobule with some predominance in the periportal area in the neonatal rat liver. This enzyme activity disappeared almost completely from the hepatocytes of young adults. However, after 30 weeks of age, there was a gradual re-elevation of the enzyme activity in the periportal hepatocytes, attaining a level similar to that of neonatal liver. Expression of gamma-GTP activity in the rat hepatocytes is associated with not only onconeonatal events but also aging.