Palladium-Catalyzed Heck-type Domino Cyclization and Carboxylation to Synthesize Carboxylic Acids by Utilizing Chloroform as the Carbon Monoxide Source.
Palladium-Catalyzed Heck-type Domino Cyclization and Carboxylation to Synthesize Carboxylic Acids by Utilizing Chloroform as the Carbon Monoxide Source.
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DOI：
10.1021/acs.joc.5b01126
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Xianglei Liu;Bin Li;Z. Gu
中科院分区：
文献类型：
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作者：
Xianglei Liu;Bin Li;Z. Gu
以三氯甲烷为一氧化碳源，研究了钯催化的多米诺环化和羧化反应，合成了多种羧酸。通过Heck环化反应原位生成的新戊基钯物种被二氯卡宾有效地捕获，形成一系列羧酸。发现在这种多米诺反应中，CHCl_3是一种方便、安全的CO气体替代物。
A palladium-catalyzed domino cyclization and carboxylation reaction for synthesis of a variety of carboxylic acids was developed, where chloroform was used as "carbon monoxide" source. The in situ generated neopentylpalladium species by Heck cyclization was efficiently trapped by dichlorocarbene to form a series of carboxylic acids. It was found that in this type of domino reaction CHCl3 is a convenient and safe alternation for CO gas.