Intermittent access to a sucrose solution for rats causes long-term increases in consumption
Intermittent access to a sucrose solution for rats causes long-term increases in consumption
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DOI：
10.1016/j.physbeh.2016.07.002
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发表时间：
2016-10-15
影响因子：
2.9
通讯作者：
Hewitt, Randelle
中科院分区：
文献类型：
--
作者：
Eikelboom, Roelof;Hewitt, Randelle
断断续续地获得美味的食物可能会使摄入量超出动物的直接需求。如果给成年雄性大鼠(可以随意获得食物和水)提供4%的蔗糖溶液，每日的蔗糖摄入量由蔗糖摄入量时间表决定：间歇性摄取蔗糖会导致高水平的摄入量。在实验1中，首先连续或每隔第二天、第三天或第四天提供蔗糖溶液，持续23.5小时，持续49天。连续获取蔗糖平均每天102g，每4天获取蔗糖平均为294g，第二天和第三天获取蔗糖的日平均消耗量介于这两个极端之间。当所有大鼠在第二阶段中隔日摄入蔗糖24天后，先前建立的摄入量差异保持不变。体重不受蔗糖摄入的影响；大鼠调整了食物摄入量，使总卡路里摄入量保持不变。在实验2中，与连续使用4%蔗糖溶液相比，每隔三天使用一次，在只接触四次蔗糖后，每天的蔗糖消耗量显著增加。随着第一阶段的缩短，蔗糖的摄入量增加。当第二阶段所有大鼠都允许隔日访问时，连续组显著增加。在实验3中，对每三天一次和连续一次的蔗糖摄入量的差异进行了逐一分析，结果表明，所有大鼠的蔗糖粉消耗量都是相同的；然而，如果是间歇性的，在第一个小时和整个24小时内，蔗糖粉的摄入量都更大。这表明，饱腹感的变化是蔗糖摄入量差异的一个机制。(C)2016 Elsevier Inc.保留所有权利。
Intermittent access to palatable food can elevate consumption beyond an animal's immediate needs. If adult male rats (with ad lib access to food and water) are provided with a 4% sucrose solution, daily sucrose consumption is determined by the sucrose access schedule: access that is intermittent leads to high levels of consumption. In Experiment 1, sucrose solutions were first provided continuously or every second, third, or fourth day for 23.5 h over 49 days. Continuous-access sucrose consumption averaged 102 g per day, while that for access every fourth day averaged 294 g. Daily consumption averages for access every second and third day fell between these two extremes. When all rats were then given alternate-day access to sucrose for 24 days in Phase II, the previously established consumption differences were maintained. Body weight was unaffected by sucrose access; rats adjusted their food consumption so that total calorie intake remained constant. In Experiment 2, compared to continuous 4% sucrose solution access, access every third day markedly elevated daily sucrose consumption after only four sucrose exposures. With this shorter Phase I, sucrose intake in. the continuous group increased markedly when in Phase II all rats were given alternate day access. In Experiment 3, a lick-by-lick analysis of the difference in sucrose consumption between access every third day and continuous access revealed that all rats were consuming a similar number of sucrose meals; however, the meals were larger both in the first hour and over the whole 24 h with intermittent access. This suggests a change in satiety as a mechanism underlying sucrose consumption difference. (C) 2016 Elsevier Inc. All rights reserved.