Secondary Motor Cortex: Where 'Sensory' Meets 'Motor' in the Rodent Frontal Cortex.
Secondary Motor Cortex: Where 'Sensory' Meets 'Motor' in the Rodent Frontal Cortex.
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DOI：
10.1016/j.tins.2016.11.006
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发表时间：
2017-03
影响因子：
15.9
通讯作者：
Kwan AC
中科院分区：
文献类型：
--
作者：
Barthas F;Kwan AC
在啮齿类动物中，次级运动皮层（M2）的内侧面有其他名称，包括内侧无颗粒皮层（medial agranular cortex）、中央前皮层（precentral cortex）和额叶定向场（frontal orienting field）。作为内侧前额叶皮层的一个细分，M2可以由一组不同的传入和传出连接、微刺激反应和损伤结果来定义。然而，M2的行为作用仍然是个谜。在这里，我们专注于啮齿动物研究的证据，强调最近的研究结果早期和上下文依赖的选择相关的活动在自愿行为的M2。基于目前的理解，我们认为，M2的一个主要功能是灵活地映射等先行信号的感觉线索的运动动作，从而使适应性选择行为。
In rodents, the medial aspect of the secondary motor cortex (M2) is known by other names including medial agranular cortex, precentral cortex, and frontal orienting field. As a subdivision of the medial prefrontal cortex, M2 can be defined by a distinct set of afferent and efferent connections, microstimulation responses, and lesion outcomes. However, the behavioral role of M2 remains mysterious. Here, we focus on evidence from rodent studies, highlighting recent findings of early and context-dependent choice-related activity in M2 during voluntary behavior. Based on the current understanding, we suggest that a major function for M2 is to flexibly map such antecedent signals as sensory cues to motor actions, thereby enabling adaptive choice behavior.