Reduced Platelet Activity Is Associated With Early Clot Growth and Worse 3-Month Outcomed After Intracerebral Hemorrhage
Reduced Platelet Activity Is Associated With Early Clot Growth and Worse 3-Month Outcomed After Intracerebral Hemorrhage
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DOI：
10.1161/strokeaha.109.550939
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发表时间：
2009-07-01
期刊：
影响因子：
8.3
通讯作者：
Batjer, H. Hunt
中科院分区：
文献类型：
--
作者：
Naidech, Andrew M.;Jovanovic, Borko;Batjer, H. Hunt
背景和目的：抗血小板药物的使用和血小板活性降低可能与脑出血（ICH）后的死亡率有关。我们测试的假设，即血小板活性降低与早期ICH凝块生长和更糟糕的outcomes. Methods，我们前瞻性地确定自发性ICH患者，入院时测量血小板活性（VerifyNow ASA，Accumetrics），并记录抗血小板药物的使用。使用计算机容量分析计算ICH体积。采用非参数统计和重复测量ANOVA（如适用）分析数据。前瞻性随访患者的功能结局。数据表示为平均值+/- SD或中位数[Q1至Q3]。
Background and Purpose-Antiplatelet medication use and reduced platelet activity may be associated with mortality after intracerebral hemorrhage (ICH). We tested the hypothesis that reduced platelet activity is associated with early ICH clot growth and worse outcomes.Methods-We prospectively identified patients with spontaneous ICH, measured platelet activity (VerifyNow-ASA, Accumetrics) on admission, and recorded antiplatelet medication use. ICH volume was calculated using computerized volumetric analysis. Data were analyzed with nonparametric statistics and repeated measures ANOVA as appropriate. Patients were prospectively followed for functional outcomes. Data are presented as mean +/- SD or median [Q1 to Q3].Results-Reduced platelet activity (