Expressions of CD133 and CD105 in lung cancer tissue and their clinical significance
Expressions of CD133 and CD105 in lung cancer tissue and their clinical significance
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作者：
Wang Shu-qin
目的：探讨肿瘤干细胞标志物CD 133和肿瘤血管内皮细胞标志物CD 105在肺癌组织中的表达及其临床意义。方法：采用免疫组化SABC法检测65例肺癌组织和30例癌旁组织中CD 133和CD 105的表达，分析其与肿瘤大小、组织学类型、分化程度、TNM分期、淋巴结转移及预后的关系。肺癌组织中CD 133和CD 105的阳性表达率显著高于癌旁组织，分别有淋巴结转移组CD 133和CD 105的阳性表达率分别为69.2%和26.7%，67.7%和10.0%，均为P0.05（82.5% vs 48.0%和80.0% vs 48.0%，均P0.05）。CD 133和CD 105的表达与淋巴结转移呈正相关，Pearson系数r分别为0.35和0.32，分别CD 133/CD 105的表达与肿瘤大小、组织学类型、分化程度及TNM分期肺癌组织中CD 133和CD 105的表达呈正相关，Pearson相关系数r = 0.37 CD 133和CD 105阳性表达组术后中位生存期明显短于CD 133和CD 105阴性表达组（分别为37个月vs 66个月，35个月vs 70个月，均P0. 05）。
Objective:To investigate the expressions of tumor stem cell marker CD133 and tumor vascular endothelial cell marker CD105 in lung cancer tissue and their clinical significance.Methods:Streptavidin-biotin-peroxidase complex(SABC)-immunohistochemical staining was used to detect the expression of CD133 and CD105 in 65 cases of lung cancer tissue and 30 specimens of adjacent non-cancerous tissue.The relationship between the expression of CD133/CD105 and tumor size,histological types,differentiation,TNM stage,lymphoid metastasis,and prognosis were analyzed.Results:The positive expression rates of CD133 and CD105 in lung cancer tissues were significantly higher than those in adjacent non cancerous tissues,respectively(69.2% vs 26.7% and 67.7% vs 10.0%,both P0.05).The positive expression rates of CD133 and CD105 in the group with lymphoid metastasis were higher than those with non lymphoid metastasis,respectively(82.5% vs 48.0% and 80.0% vs 48.0%,both P0.05).The expressions of CD133 and CD105 were positively correlated with lymphoid metastasis with Pearson coefficient r of 0.35 and 0.32,respectively(P0.05).No significant correlation was found between the expression of CD133/CD105 and tumor size,histological types,differentiation degree as well as TNM stage(P0.05).The expression of CD133 was positively correlated with the expression of CD105 in lung cancer tissue with Pearson coefficient r of 0.37(P0.05).Postoperative median survival periods of CD133 and CD105-positive group were significantly shorter than the CD133 and CD105-negative groups(37 months vs 66 months,35 months vs 70 months,respectively,both P0.05).Conclusion:The expression of CD133 and CD105 was associated with lymphoid metastasis and prognosis in patients with lung cancer.Their overexpression implies poor prognosis of lung cancer patients.