Do Sociodemographic Factors Influence Outcome in Prostate Cancer Patients Treated With External Beam Radiation Therapy?
Do Sociodemographic Factors Influence Outcome in Prostate Cancer Patients Treated With External Beam Radiation Therapy?
复制标题
DOI：
10.1097/coc.0000000000000093
复制
发表时间：
2016-12-01
影响因子：
2.6
通讯作者：
Siddiqui, Farzan
中科院分区：
文献类型：
--
作者：
Movsas, Avielle;Ibrahim, Ramy;Siddiqui, Farzan
目的：本研究的目的是分析社会人口因素对前列腺癌患者生化控制（bNED）和总生存期（OS）的预后意义。方法：对1997年至2006年接受确定性外照射放射治疗（EBRT）+/-激素治疗的前列腺癌患者进行IRB批准的研究。从电子病历中获得患者人口统计学资料、治疗（Tx）和临床结局。从2000年人口普查数据中获得了人口普查区块组一级的家庭收入中位数。关于疾病和Tx参数的数据包括Gleason评分、Tx前前列腺特异性抗原（PSA）、T分期、Tx年份、EBRT剂量和激素治疗的使用。患者被分为低风险、中风险或高风险疾病。社会人口因素包括年龄、种族、婚姻状况和mHHI。生化失败定义为最低PSA + 2 ng/mL。OS是基于任何原因的死亡。结果：共788例连续患者进行了研究，平均随访7年（范围，0.4至15年）。非裔美国人占患者的48%，而46%的患者是白色，6%是其他种族。白人的平均mHHI为60,190美元，而非裔美国人为36,917美元（P
Objectives: The purpose of this study was to analyze the prognostic significance of sociodemographic factors on biochemical control (bNED) and overall survival (OS) in patients with prostate cancer.Methods: Prostate cancer patients treated with definitive external beam radiation therapy (EBRT) +/- hormone therapy from 1997 to 2006 were analyzed in this IRB-approved study. Patient demographics, treatment (Tx), and clinical outcome were obtained from electronic medical records. Median household income (mHHI) at the census block group level was obtained from the 2000 census data. Data on disease and Tx parameters included Gleason score, pre-Tx prostate specific antigen (PSA), T stage, year of Tx, EBRT dose, and use of hormone therapy. Patients were categorized as having low-risk, intermediate-risk, or high-risk disease. Sociodemographic factors included age, race, marital status, and mHHI. Biochemical failure was defined as nadir PSA + 2 ng/mL. OS was based on death from any cause.Results: A total of 788 consecutive patients were studied with a median follow-up of 7 years (range, 0.4 to 15 y). African Americans comprised 48% of the patients, whereas 46% of patients were white and 6% were other races. Whites had an average mHHI of $60,190 compared with $36,917 for African Americans (P