Long-Term Air Pollution Exposure and Blood Pressure in the Sister Study.
Long-Term Air Pollution Exposure and Blood Pressure in the Sister Study.
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DOI：
10.1289/ehp.1408125
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发表时间：
2015-10
影响因子：
10.4
通讯作者：
Sandler DP
中科院分区：
文献类型：
--
作者：
Chan SH;Van Hee VC;Bergen S;Szpiro AA;DeRoo LA;London SJ;Marshall JD;Kaufman JD;Sandler DP
暴露于空气污染一直与心血管疾病发病率和死亡率有关，但机制仍不确定。与血压（BP）的关联可能有助于解释空气污染对心血管的影响。我们在国家环境健康科学研究所的姊妹研究中研究了长期（年平均）住宅空气污染暴露与BP之间的横断面关系，这是一项调查乳腺癌风险因素和其他结果的大型美国队列研究。这项分析包括了43,629名年龄在35-76岁之间的女性，她们在2003-2009年登记，她们的姐妹患有乳腺癌。地理信息系统有助于在研究开始时在参与者住所进行基于卫星的二氧化氮（NO2）和细颗粒物（≤2.5 μm; PM2.5）预测。在研究开始时，使用广义加性模型来检验污染物与测量血压之间的关系，调整心血管疾病的危险因素，并包括潜在的空间混淆的薄板样条。PM2.5升高10 μg/m3与收缩压升高1.4 mmhg （95% CI: 0.6, 2.3, p < 0.001）、脉压升高1.0 mmhg （95% CI: 0.4, 1.7, p = 0.001）、平均动脉压升高0.8 mmhg （95% CI: 0.2, 1.4, p = 0.01）相关，与舒张压无显著相关性。NO2浓度每增加10 ppb，脉压升高0.4 mmhg （95% CI: 0.2, 0.6; p < 0.001）。长期暴露在PM2.5和二氧化氮中与高血压有关。在人口规模上，这种与空气污染相关的血压升高可能在一定程度上解释了先前研究中心血管疾病发病率和死亡率的增加。Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP。2015. 姐妹研究中的长期空气污染暴露与血压的关系。环境健康展望123:951-958；http://dx.doi.org/10.1289/ehp.1408125
Exposure to air pollution has been consistently associated with cardiovascular morbidity and mortality, but mechanisms remain uncertain. Associations with blood pressure (BP) may help to explain the cardiovascular effects of air pollution. We examined the cross-sectional relationship between long-term (annual average) residential air pollution exposure and BP in the National Institute of Environmental Health Sciences’ Sister Study, a large U.S. cohort study investigating risk factors for breast cancer and other outcomes. This analysis included 43,629 women 35–76 years of age, enrolled 2003–2009, who had a sister with breast cancer. Geographic information systems contributed to satellite-based nitrogen dioxide (NO2) and fine particulate matter (≤ 2.5 μm; PM2.5) predictions at participant residences at study entry. Generalized additive models were used to examine the relationship between pollutants and measured BP at study entry, adjusting for cardiovascular disease risk factors and including thin plate splines for potential spatial confounding. A 10-μg/m3 increase in PM2.5 was associated with 1.4-mmHg higher systolic BP (95% CI: 0.6, 2.3; p < 0.001), 1.0-mmHg higher pulse pressure (95% CI: 0.4, 1.7; p = 0.001), 0.8-mmHg higher mean arterial pressure (95% CI: 0.2, 1.4; p = 0.01), and no significant association with diastolic BP. A 10-ppb increase in NO2 was associated with a 0.4-mmHg (95% CI: 0.2, 0.6; p < 0.001) higher pulse pressure. Long-term PM2.5 and NO2 exposures were associated with higher blood pressure. On a population scale, such air pollution–related increases in blood pressure could, in part, account for the increases in cardiovascular disease morbidity and mortality seen in prior studies. Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP. 2015. Long-term air pollution exposure and blood pressure in the Sister Study. Environ Health Perspect 123:951–958; http://dx.doi.org/10.1289/ehp.1408125