Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study.
Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study.
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醛固酮合酶启动子多态性和心血管表型中的大型，基于多种族的研究。
DOI：
10.1097/jim.0000000000000220
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
White PC
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文献类型：
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作者：
Byrd JB;Auchus RJ;White PC
醛固酮合成酶基因(CYP11B2)启动子[-344C/t，rs1799998]单核苷酸多态性与心血管表型相关。达拉斯心脏研究是一个高血压患病率很高的大型多民族队列研究。我们对3452名达拉斯心脏研究受试者进行了-344C/T基因分型，并使用广义线性模型来评估-344C/T的变异是否与血浆醛固酮浓度(PAC)、收缩压和舒张压(SBP和DBP)、血糖(非糖尿病患者)、HOMA IR(稳态模型评估作为胰岛素抵抗指数)以及左心室重量(LV)指数与身高有关。黑人的收缩压和舒张压明显高于白人(收缩压和舒张压分别为0.001)和西班牙裔(收缩压和舒张压分别为0.001)。黑人的对数转换体重指数也显著高于白人(P<；0.001)，但拉美裔没有(P=0.1)。对数转换后的PAC在白人中高于黑人(P<；0.001)，但在白人中与拉美裔相比没有显著差异(P=0.73)。在单变量和多变量分析中，-344C/T与任何种族的PAC均无显著关联。在单变量和多变量分析中，-344C/T与任何种族的SBP和DBP无关。在调整了多项测试后，单变量和多变量分析显示，在没有糖尿病、HOMA IR或以身高为指标的LV质量指数的患者中，-344C/T与血糖之间没有关联。我们无法复制先前报道的-344C/T与PAC、血压、血糖或左心室重量之间的关系。方法论上的差异可能解释了我们的发现与之前报道的结果之间的差异
A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [–344c/t, rs1799998] has been reported to associate with cardiovascular phenotypes. The Dallas Heart Study is a large, multiethnic cohort with a high prevalence of hypertension. We genotyped 3452 Dallas Heart Study participants for –344C/T. Generalized linear models were used to assess whether variation at –344C/T associated with plasma aldosterone concentration (PAC), systolic and diastolic blood pressure (SBP and DBP), plasma glucose (in persons with no diabetes), HOMA IR (Homeostasis Model Assessment as an Index of Insulin Resistance), and left ventricular (LV) mass indexed to height. Systolic blood pressure and DBP were significantly higher in blacks compared with whites (P < 0.001 for SBP and for DBP) and Hispanics (P < 0.001 for SBP and for DBP). Log-transformed body mass index was also significantly higher in blacks compared with whites (P < 0.001), but not Hispanics (P = 0.10). Log-transformed PAC was higher in whites compared with blacks (P < 0.001), but did not differ significantly in whites compared with Hispanics (P = 0.73). In univariate and multivariable analysis, –344C/T was not significantly associated with PAC within any ethnicity. In univariate and multivariable analysis, –344C/T was not associated with SBP or DBP within any ethnicity. After adjustment for multiple testing, univariate and multivariable analyses revealed no association between –344C/T and plasma glucose in patients with no diabetes, HOMA IR, or LV mass indexed to height. We were unable to reproduce previously reported associations between –344C/T and PAC, blood pressure, plasma glucose, or LV mass. Methodological differences might explain the differences between our findings and those previously reported