Peripheral neuroblastic tumors: Pathologic classification based on recommendations of International Neuroblastoma Pathology Committee (Modification of Shimada classification)
Peripheral neuroblastic tumors: Pathologic classification based on recommendations of International Neuroblastoma Pathology Committee (Modification of Shimada classification)
复制标题
DOI：
10.1007/s100240050024
复制
发表时间：
2000-03-01
影响因子：
1.9
通讯作者：
Joshi, VV
中科院分区：
文献类型：
--
作者：
Joshi, VV
一般建议一组肿瘤的形态学分类应简单、可重复、易学、易教，并具有预后意义。外周神经母细胞肿瘤（nt）是一组异质性的肿瘤，它们不适合简单的、易于学习和教授的具有病理性和预后意义的形态学分类，因为它们具有以下特点：nt出现在不同的部位；它们表现出复杂的、不熟悉的大体和微观特征；它们没有被广泛接受和广泛使用的指定类型和亚型的统一术语和标准；它们的诊断通常基于原发部位或转移部位的切口活检，其中只有一小部分肿瘤可能不具有代表性，可用于病理检查。此外，在试图通过将nt的形态学和生物学相关联来解释形态学分类的生物学相关性时，病理学家还必须考虑在不同治疗方案的分层中使用的成熟的遗传预后标记。由于NT的病理分类很复杂，并且根据儿科肿瘤组/儿童癌症组（POG/CCG） NT治疗方案，需要对每个入组病例进行预后分类，以便将病例分配到特定的方案中，因此需要根据国际神经母细胞瘤病理委员会（INPC）推荐的术语和分类进行集中审查，以确定NT的类型和亚型及其预后类别[1]。2]。
It is generally recommended that morphologic classification of a group of tumors be simple, reproducible, easy to learn, easy to teach, and of prognostic significance. Peripheral neuroblastic tumors (NTs) are a heterogeneous group of tumors that do not lend themselves to a simple, readily reproducible morphologic classification of nosologic and prognostic significance that is easy to learn and easy to teach, because of the following features: NTs arise at various sites; they exhibit complex, unfamiliar gross and microscopic features; they do not have widely accepted and widely used uniform terminology and criteria for designation of types and subtypes; and they are often diagnosed on the basis of an incisional biopsy of the primary or a metastatic site in which only a small, possibly nonrepresentative portion of the tumor may be available for pathologic examination. Furthermore, in an attempt to explain biologic relevance of morphologic classification by correlating morphology and biology of NTs, the pathologist also has to take into consideration the well-established genetic prognostic markers used in stratification for different therapeutic protocols. Since the pathologic classification of NTs is complex and, according to Pediatric Oncology Group/Children’s Cancer Group (POG/CCG) protocols for therapy of NTs, prognostic categorization needs to be confirmed in each enrolled case for assigning the case to a specific protocol, a central review is required to determine the type and subtype of NT and its prognostic category according to the terminology and classification recommended by the International Neuroblastoma Pathology Committee (INPC)[1, 2].