POST-EMBRYONIC CELL LINEAGES OF NEMATODE, CAENORHABDITIS-ELEGANS
POST-EMBRYONIC CELL LINEAGES OF NEMATODE, CAENORHABDITIS-ELEGANS
复制标题
DOI：
10.1016/0012-1606(77)90158-0
复制
发表时间：
1977-01-01
影响因子：
2.7
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
SULSTON, JE;HORVITZ, HR
自由生活的土壤线虫C. elegans从. apprx. 550在新孵化的幼虫到. apprx。810在成熟的雌雄同体和. apprx. 970在成熟的男性。导致这种增加的细胞分裂模式在个体之间基本上是不变的;严格确定的细胞谱系产生固定数量的后代细胞，这些后代细胞具有严格指定的命运。这些谱系的长度范围从1-8个连续分裂，并导致神经元，肌肉，皮下和消化系统的显着发育变化。通常，几个母细胞遵循相同的不对称分裂程序;这些细胞的直系等价后代通常分化为功能等价的细胞。通过直接观察活线虫中单个细胞的分裂、迁移和死亡来确定这些细胞谱系。许多细胞谱系参与性成熟。在孵化时，雌雄同体和男性几乎是相同的形态;到成年阶段，总的解剖学差异是明显的。这些性别差异中的一些是由原始细胞引起的，原始细胞的分裂模式最初在雄性和雌雄同体中是相同的，但后来就不同了。在雌雄同体中，这些细胞产生用于产卵和交配的结构，而在雄性中，它们产生形态上不同的结构，这些结构在交配之前和期间发挥作用。雄性动物的发育涉及到许多来源于雌雄同体中不分裂的细胞的谱系。类似的胚后发育事件发生在其他线虫物种。
The number of nongonadal nuclei in the free-living soil nematode C. elegans increases from .apprx. 550 in the newly hatched larva to .apprx. 810 in the mature hermaphrodite and to .apprx. 970 in the mature male. The pattern of cell divisions which leads to this increase is essentially invariant among individuals; rigidly determined cell lineages generate a fixed number of progeny cells of strictly specified fates. These lineages range in length from 1-8 sequential divisions and lead to significant developmental changes in the neuronal, muscular, hypodermal and digestive systems. Frequently, several blast cells follow the same asymmetric program of divisions; lineally equivalent progeny of such cells generally differentiate into functionally equivalent cells. These cell lineages were determined by direct observation of the divisions, migrations and deaths of individual cells in living nematodes. Many of the cell lineages are involved in sexual maturation. At hatching, the hermaphrodite and male are almost identical morphologically; by the adult stage, gross anatomical differences are obvious. Some of these sexual differences arise from blast cells whose division patterns are initially identical in the male and in the hermaphrodite but later diverge. In the hermaphrodite, these cells produce structures used in egg-laying and mating, whereas in the male they produce morphologically different structures which function before and during copulation. Development of the male involves a number of lineages derived from cells which do not divide in the hermaphrodite. Similar postembryonic developmental events occur in other nematode species.