Polychlorbiphenyls (PCB) induced fetopathy. I. Clinical observation.
Polychlorbiphenyls (PCB) induced fetopathy. I. Clinical observation.
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多氯联苯 (PCB) 诱发胎儿病。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
Ichiro Ide
中科院分区：
文献类型：
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作者：
Iichiro Funatsu;Fumio Yamashita;Y. Ito;Shin Tsugawa;Takako Funatsu;Takashi Yoshikane;Masao Hayashi;Toshi Kato;Michiaki Yakushiji;Gen Okamoto;Seiichiro Yamasaki;Tadashi Arima;T. Kuno;H. Ide;Ichiro Ide
详细研究了四个婴儿的中毒母亲，由于米油污染的多氯联苯（日本Yusho）。这些婴儿表现出异常的临床特征，为新的临床实体，可称为多氯联苯（PCB）诱导的胎儿病。其主要特点是：1）宫内发育迟缓（3/4例为小孕婴）;（2）皮肤及粘膜深褐色色素沉着，与Addison病相似，尤以生殖器、腋窝、指甲附近、毛囊及口腔、眼睑、边缘结膜粘膜为多;（3）牙龈增生3例，4）顶枕部点状钙化3例，额、枕部及矢状缝较大或较宽; 5）面部水肿、眼球突出3例。推测内分泌和酶因子在胎儿病发病机制中的可能存在。
Four babies born to the poisned mother due to rice oil contaminated with polychlorbiphenyls (Yusho in Japanese) were studied in detail. These babies showed the unusual clinical features which were new clinical entity and might be called as polychlorbiphenyls (PCB) induced fetopathy. The main features were : 1) Intrauterine retardation of the growth (Small-For-Dates Baby in 3 of 4 cases), 2) Dark brown pigmentation on the skin and mucous membrane similar to that in Addison's disease, especially on the skin of the genitalia, axilla, near finger nail, hair follicle and on the mucous membrane of the mouth, palpebra, and limbic conjunctiva, 3) gingival hyperplasia in 3, and the eruption of teeth at birth in 2 cases, 4) Spotted cacification on the parieto-occipital skull in 3 cases and the large or wide frontal and occipital fontanells and saggital suture, 5) edematous face and exophthalmic eye in 3 cases. Possible presence of endocrinologic and enzymatic factor in the pathogenesis of this fetopathy was speculated.