Targeting the Adipose Tissue in COVID-19
Targeting the Adipose Tissue in COVID-19
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DOI：
10.1002/oby.22844
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发表时间：
2020-05-21
期刊：
影响因子：
6.9
通讯作者：
Iacobellis, Gianluca
中科院分区：
文献类型：
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作者：
Malavazos, Alexis Elias;Romanelli, Massimiliano Marco Corsi;Iacobellis, Gianluca
世界卫生组织认为肥胖等非传染性疾病是 2019 年新型冠状病毒 (COVID-19) 重症的主要风险因素(1)。英国重症监护国家审计和研究中心的一项研究表明，出现严重或致命的 COVID-19 相关并发症的人中有三分之二患有超重或肥胖 (2)。该报告包含截至 2020 年 3 月 19 日午夜之前英国重症监护病房所有入院的 COVID-19 患者的数据。该研究显示，重症监护病房中近 72% 的患者体重超重或肥胖，这表明肥胖对重症 COVID-19 患者的影响。在 COVID-19 爆发之初，意大利国家卫生研究院 (Instituto Superiore di Sanità) 启动了一个监测系统，收集整个地区所有 COVID-19 患者的信息。国家。所有 COVID-19 病例的数据均来自意大利所有 19 个地区以及特伦托和博曾 2 个自治区 (3)。来自意大利的报告表明，99% 的死亡发生在患有非传染性疾病的患者中，例如肥胖、高血压、2 型糖尿病、心脏病、肾损伤和癌症 (3)。截至 2020 年 4 月 2 日，12,250 名 50 岁以下的 COVID-19 阳性患者中，有 145 名 (1.2%) 死亡。特别是，其中 35 人年龄在 40 岁以下，其中男性 94 人，女性 26 人（年龄范围在 26 岁至 39 岁之间）。对于14名40岁以下的患者，没有可用的临床信息；其余 18 人患有严重的既往病症，例如严重肥胖及其合并症（心血管、肾脏、糖尿病和精神病症），3 人没有重大病症 (3)。
The World Health Organization considers noncommunicable diseases, such as obesity, to be a major risk factor for becoming seriously ill with 2019 novel coronavirus (COVID-19)(1). A study by the UK Intensive Care National Audit and Research Centre indicates that two-thirds of people who have developed serious or fatal COVID-19–related complications had overweight or obesity (2). The report includes data from all COVID-19 admissions in intensive care units in the UK until midnight, March 19, 2020. The study shows that almost 72% of those in critical care units had either overweight or obesity, suggesting the impact of obesity in seriously ill COVID-19 patients.At the outset of the COVID-19 outbreak, the Italian National Institute of Health (Instituto Superiore di Sanità) launched a surveillance system to collect information on all people with COVID-19 throughout the country. Data on all COVID-19 cases were obtained from all 19 Italian regions and the 2 autonomous provinces of Trento and Bozen (3). The report from Italy indicates that 99% of deaths occurred in patients with preexisting noncommunicable diseases, such as obesity, hypertension, type 2 diabetes mellitus, heart disease, kidney damage, and cancer (3). As of April 2, 2020, 145 of the 12,250 (1.2%) COVID-19–positive patients under the age of 50 have died. In particular, 35 of these were less than 40 years, 94 men and 26 women (age range between 26 and 39 years). For 14 patients under the age of 40 years, no clinical information is available; the remaining 18 had serious preexisting pathologies, such as severe obesity and its comorbidities (cardiovascular, renal, diabetes mellitus, and psychiatric pathologies), and 3 had no major pathologies (3).