Diffuse and focal oxygen pneumonitis. A preliminary report on the threshold of pulmonary oxygen toxicity in man.
Diffuse and focal oxygen pneumonitis. A preliminary report on the threshold of pulmonary oxygen toxicity in man.
复制标题
弥漫性和局灶性氧性肺炎。
DOI：
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发表时间：
1974
影响因子：
3.4
通讯作者：
S. Sevitt
中科院分区：
文献类型：
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作者：
S. Sevitt
以肺透明膜和增生性肺炎作为肺氧毒性的证据，21例氧疗后死亡患者（19例受伤，2例吸入烟雾）肺部变化与给氧强度和时间相关。在10例（或11例）受试者中发现弥漫性肺炎引起低氧血症，其中9例与高浓度氧气（60 - 100%）呼吸至少2天有关。至少有8名受试者死于肺炎，另外两名存活数周的患者肺部广泛纤维化。在足够的时间内呼吸40%的氧气似乎是危险肺部影响的阈值，因为一名患者在暴露于该浓度时出现弥漫性肺炎，另一名患者出现部分弥漫性部分局灶性肺炎。那些连续数天呼吸氧浓度在25 - 40%之间的患者要么出现亚临床局灶性肺病变，要么没有相关的肺变化。
Utilizing hyaline membranes and proliferative pneumonitis as evidence of pulmonary oxygen toxicity, the lung changes in 21 patients (19 injured, two inhaled smoke) who died after oxygen therapy are correlated with the intensity and duration of oxygen administration. Diffuse pneumonitis inducing hypoxaemia was found in 10 (or 11) subjects, and in nine of them it was associated with the breathing of high concentrations of oxygen (60 to 100%) for at least two days. In at least eight subjects the pneumonitis contributed to death, and two others who survived for weeks had extensively fibrosed lungs. The breathing of 40% oxygen for a sufficient time seems to be a threshold for dangerous lung effects, since one patient developed a diffuse pneumonitis and another a partly-diffuse partly-focal pneumonitis while exposed to this concentration. Those respiring oxygen concentrations between 25 and 40% for days developed either subclinical focal lung lesions or had no relevant lung changes.