Interactions Between Keratinocytes and Somatosensory Neurons in Itch
Interactions Between Keratinocytes and Somatosensory Neurons in Itch
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DOI：
10.1007/978-3-662-44605-8_10
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发表时间：
2015-01-01
期刊：
影响因子：
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通讯作者：
Bautista, Diana M.
中科院分区：
文献类型：
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作者：
Schwendinger-Schreck, Jamie;Wilson, Sarah R.;Bautista, Diana M.
角质细胞是构成皮肤复层表皮的上皮细胞。最近的研究表明角质形成细胞会促进慢性瘙痒。伴随各种慢性瘙痒症的皮肤形态变化以及针对感觉神经元和免疫细胞的角质形成细胞分泌的多种炎症介质凸显了研究角质形成细胞与慢性瘙痒之间联系的重要性。本章介绍了角质形成细胞在慢性瘙痒的发展和维持中所发挥的作用的一些最新数据和模型。
Keratinocytes are epithelial cells that make up the stratified epidermis of the skin. Recent studies suggest that keratinocytes promote chronic itch. Changes in skin morphology that accompany a variety of chronic itch disorders and the multitude of inflammatory mediators secreted by keratinocytes that target both sensory neurons and immune cells highlight the importance of investigating the connection between keratinocytes and chronic itch. This chapter addresses some of the most recent data and models for the role keratinocytes play in the development and maintenance of chronic itch.