Epidemiology of chronic liver diseases in the USA in the past three decades
Epidemiology of chronic liver diseases in the USA in the past three decades
复制标题
DOI：
10.1136/gutjnl-2019-318813
复制
发表时间：
2020-03-01
期刊：
影响因子：
24.5
通讯作者：
Henry, Linda
中科院分区：
文献类型：
--
作者：
Younossi, Zobair M.;Stepanova, Maria;Henry, Linda
鉴于病毒性肝炎治疗的显著进展和肥胖症的日益流行，美国不同类型肝病的负担可能正在发生变化。我们的目的是评估过去三十年来美国不同肝病病因患病率的变化。使用了设计国家健康和营养检查调查（NHANES;横截面1988-1994和1999-2016）。结果NHANES（1988-2016）共纳入58 731名成年人。在研究期间，慢性B型肝炎和酒精性肝病的患病率保持稳定：分别为0.3%-0.4%和0.8%-1.0%（p>0.05）。慢性丙型肝炎的患病率下降了近两倍：1988-1994年为1.6%，2013-2016年为0.9%（p=0.03）。相比之下，非酒精性脂肪肝（NAFLD;根据美国脂肪肝指数）的患病率从20.0%（1988-1994）增加到28.3%（1999-2004），增加到33.2%（2009-2012）和31.9%（2013-2016）（p
Objective Given significant advances in treatment of viral hepatitis and the growing epidemic of obesity, the burden of the different types of liver diseases in the USA may be changing. Our aim was to assess the shift in the prevalence of different liver disease aetiologies in the USA over the past three decades.Design National Health and Nutrition Examination Surveys (NHANES; cross-sectional 1988-1994 and 1999-2016) were used.Results A total of 58 731 adults from NHANES (1988-2016) were included. Over the study period, the prevalence of chronic hepatitis B and alcoholic liver disease remained stable: 0.3%-0.4% and 0.8%-1.0%, respectively (p>0.05). The prevalence of chronic hepatitis C decreased nearly twofold: 1.6% in 1988-1994 to 0.9% in 2013-2016 (p=0.03). In contrast, the prevalence of non-alcoholic fatty liver disease (NAFLD; by US-Fatty Liver Index) increased from 20.0% (1988-1994) to 28.3% (1999-2004) to 33.2% (2009-2012) and 31.9% (2013-2016) (p