Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma.
Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma.
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DOI：
10.1038/bjc.1995.331
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发表时间：
1995-08
影响因子：
8.8
通讯作者：
Sowa, M.
中科院分区：
文献类型：
--
作者：
Maeda, K.;Chung, Y.-S.;Takatsuka, S.;Ogawa, Y.;Onoda, N.;Sawada, T.;Kato, Y.;Nitta, A.;Arimoto, Y.;Kondo, Y.;Sowa, M.
肿瘤的生长依赖于新生血管和肿瘤细胞的增殖。因子viii相关抗原（F-VIII RA）定位于血管内皮。增殖细胞核抗原（PCNA）的表达与细胞增殖有关。我们研究了这些抗原的表达与胃癌预后的关系。采用抗F-VIII RA单克隆抗体和PCNA单克隆抗体对108例胃癌标本进行染色。测定微血管计数（MVC， 200倍放大时血管密度最高的5个区域的平均微血管数）和PCNA标记指数（PCNA LI， 500多个肿瘤细胞中阳性细胞的百分比）。结果显示，与低MVC（小于16）或低PCNA LI（小于42%）的肿瘤患者相比，高MVC（大于16）或高PCNA LI（大于42%）的肿瘤患者的预后明显更差。此外，MVC与肝脏复发风险显著相关。综上所述，MVC和PCNA LI可能是胃癌患者良好的预后指标。
Tumour growth depends on neovascularisation and tumour cell proliferation. Factor VIII-related antigen (F-VIII RA) localises to vascular endothelium. Expression of proliferating cell nuclear antigen (PCNA) is correlated with cell proliferation. We investigated the correlation between the expression of these antigens and prognosis in gastric carcinoma. A total of 108 specimens resected from patients with gastric carcinoma were investigated by staining with monoclonal antibodies against F-VIII RA and PCNA. Microvessel count (MVC; the mean number of microvessels in the five areas of highest vascular density at 200 x magnification) and PCNA labelling index (PCNA LI; percentage of positive cells in more than 500 tumour cells) were determined. The results showed that prognosis was significantly worse in patients who had a tumour with a high MVC (16 or greater) or a high PCNA LI (42% or greater) than in those patients who had a tumour with a low MVC (less than 16) or a low PCNA LI (less than 42%). Furthermore, MVC was significantly associated with the risk of hepatic recurrence. In conclusion, both MVC and PCNA LI may be good prognostic indicators in patients with gastric carcinoma.
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影响因子：
10.3
作者：
WEIDNER, N;FOLKMAN, J;GASPARINI, G
通讯作者：
GASPARINI, G
影响因子：
6.4
作者：
TOI, M;KASHITANI, J;TOMINAGA, T
通讯作者：
TOMINAGA, T
影响因子：
45.3
作者：
GASPARINI, G;WEIDNER, N;POZZA, F
通讯作者：
POZZA, F
影响因子：
8.8
作者：
Bouzubar, N;Walker, K J;Griffiths, K;Ellis, I O;Elston, C W;Robertson, J F;Blamey, R W;Nicholson, R I
通讯作者：
Nicholson, R I
影响因子：
3.7
作者：
LANDBERG, G;TAN, EM;ROOS, G
通讯作者：
ROOS, G