Revising our attitudes towards agonist medications and their diversion in a time of pandemic.
Revising our attitudes towards agonist medications and their diversion in a time of pandemic.
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DOI：
10.1016/j.jsat.2020.108139
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发表时间：
2020-12
影响因子：
3.9
通讯作者：
Rich JD
中科院分区：
文献类型：
--
作者：
Del Pozo B;Rich JD
新冠肺炎疫情导致政府监管机构放宽了丁丙诺啡和美沙酮的处方规则。丁丙诺啡和美沙酮是两种有效治疗阿片类药物使用障碍的激动剂药物，允许患者最多带回家28天。这些变化优先考虑这些药物的可获得性，而不是对其滥用和转移的担忧，它们为在大流行高度不确定的情况下进行过量预防提供了一种手段。在考虑如何利用这一转变时，研究应该确定结果是在多大程度上发生了更多的转移，以及可能产生的后果。这些转变还为考虑美沙酮是否可以在初级保健环境中安全地开出处方，以及如果对转移的担忧持续存在，每月注射丁丙诺啡是否是增加舌下牙条供应的合适替代方案奠定了基础。大流行的破坏导致过量死亡人数激增，因此，仔细考虑激动剂药物的预防潜力，以及它们作为治疗的作用，可能有助于我们解决这一死亡危机。
The COVID-19 pandemic led government regulators to relax prescribing rules for buprenorphine and methadone, the agonist medications that effectively treat opioid use disorder, allowing for take home supplies of up to 28 days. These changes prioritized the availability of these medications over concerns about their misuse and diversion, and they provided a means for overdose prophylaxis during the highly uncertain conditions of the pandemic. In considering how to capitalize on this shift, research should determine the extent to which increased diversion has occurred as a result, and what the consequences may have been. The shifts also set the stage to consider if methadone can be safely prescribed in primary care settings, and if the monthly injectable formulation of buprenorphine is a suitable alternative to increased supplies of sublingual strips if concerns about diversion persist. The disruptions of the pandemic have caused a surge in overdose deaths, so carefully considering the prophylactic potential of agonist medications, in addition to their role as a treatment, may help us address this mortality crisis.
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影响因子：
5.5
作者：
Carroll, Jennifer J.;Rich, Josiah D.;Green, Traci C.
通讯作者：
Green, Traci C.
影响因子：
3.9
作者：
Tompkins, Charlotte N. E.;Neale, Joanne;Strang, John
通讯作者：
Strang, John
DOI：
10.1016/j.drugpo.2020.102701
发表时间：
2020-11
期刊：
The International journal on drug policy
影响因子：
--
作者：
Cooper HL;Cloud DH;Freeman PR;Fadanelli M;Green T;Van Meter C;Beane S;Ibragimov U;Young AM
通讯作者：
Young AM
DOI：
10.1177/1073110520935353
发表时间：
2020-06
期刊：
The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
影响因子：
--
作者：
Pozo BD;Krasner LS;George SF
通讯作者：
George SF
影响因子：
4.4
作者：
Carlson, Robert G.;Daniulaityte, Raminta;Silverstein, Sydney M.;Nahhas, Ramzi W.;Martins, Silvia S.
通讯作者：
Martins, Silvia S.