Axonal translation of β-catenin regulates synaptic vesicle dynamics.
Axonal translation of β-catenin regulates synaptic vesicle dynamics.
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DOI：
10.1523/jneurosci.2944-12.2013
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发表时间：
2013-03-27
期刊：
影响因子：
--
通讯作者：
Schuman EM
中科院分区：
文献类型：
--
作者：
Taylor AM;Wu J;Tai HC;Schuman EM
Many presynaptic transcripts have been observed in axons, yet their role in synapse development remains unknown. Using visually and pharmacologically isolated presynaptic terminals from dissociated rat hippocampal neurons, we found that ribosomes and β-catenin mRNA preferentially localize to recently formed boutons. Locally translated β-catenin accumulates at presynaptic terminals where it regulates synaptic vesicle release dynamics. Thus, local translation of β-catenin is a newly described mechanism for axons to independently functionalize nerve terminals at great distances from cellular somata.
