Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis.
Next-Generation o-Nitrobenzyl Photolabile Groups for Light-Directed Chemistry and Microarray Synthesis.
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DOI：
10.1002/anie.201502125
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发表时间：
2015-07-13
期刊：
影响因子：
--
通讯作者：
Somoza MM
中科院分区：
文献类型：
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作者：
Kretschy N;Holik AK;Somoza V;Stengele KP;Somoza MM
光作为一种外部触发，是一种宝贵且易于控制的工具，可以高空间和高时间精度地指导化学反应。两个邻硝基苯基衍生物，苯甲酰基和硫苯基NPPOC，经历了光脱保护，比通常使用的NPPOC基团的效率显著提高。通过光刻合成微阵列，证明了光解保护效率提高了两倍和十二倍。
Light as an external trigger is a valuable and easily controllable tool for directing chemical reactions with high spatial and temporal accuracy. Two o-nitrobenzyl derivatives, benzoyl- and thiophenyl-NPPOC, undergo photo-deprotection with significantly improved efficiency over that of the commonly used NPPOC group. The two- and twelvefold increase in photo-deprotection efficiency was proven using photolithograph synthesis of microarrays.