Health effects of chronic exposure to polychlorinated dibenzo-P-dioxins (PCDD), dibenzofurans (PCDF) and coplanar PCB (Co-PCB) of municipal waste incinerator workers.
Health effects of chronic exposure to polychlorinated dibenzo-P-dioxins (PCDD), dibenzofurans (PCDF) and coplanar PCB (Co-PCB) of municipal waste incinerator workers.
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城市垃圾焚烧厂工人长期接触多氯二苯并-对-二恶英 (PCDD)、二苯并呋喃 (PCDF) 和共面 PCB (Co-PCB) 对健康的影响。
DOI：
10.2188/jea.10.262
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发表时间：
2000
影响因子：
4.7
通讯作者：
Tsutomu Takada
中科院分区：
文献类型：
--
作者：
K. Kitamura;Yuriko Kikuchi;Yuriko Kikuchi;Shaw Watanabe;Gabriel Waechter;Haruhiko Sakurai;Tsutomu Takada
1997年对城市垃圾焚烧炉排放气体中的多氯二苯并对二恶英(PCDD)和二苯并呋喃(PCDF)进行的全国调查显示，Nose Bika中心受到PCDF的严重污染。94名工人接受了体检，并进行了血液生化、淋巴细胞标志物和NK活性研究，同时进行了血液二恶英测定。采用问卷调查法和访谈法对调查对象的职业史、生活方式、饮食习惯等进行调查。血液中的二恶英水平如下。二恶英的TEQ中位数为39.7pgI-TEQ/g脂肪，范围为13.3%~805.8。2，3，7，8-TCDD浓度中位数为3.9pgTEQ/g脂肪，范围为-lt；1pgTEQ/g脂肪(1例)至13.4pgTEQ/g脂肪。共面印刷电路板的TEQ中位数为10.8pgI-TEQ/g脂肪，范围为3.1~54.2pgTEQ/g脂肪。同系物的特定分布与焚烧炉周围土壤和工厂垃圾中的分布非常相似。二恶英浓度与工厂工作历史的关系表明，流态化焚烧炉和飞灰处理区是高危工作区。相关分析表明，二恶英水平与GGT、总蛋白、尿酸、钙呈显著正相关，与铁呈显著负相关。然而，这些相关性在根据年龄、吸烟状况和饮酒情况进行调整的多变量分析后消失了。即使在调整了年龄后，NK活性增加和对PHA刺激的反应降低仍然显著。高脂血症和过敏史显著增加优势比。一项关于同类型焚烧炉对其他工人的风险的研究正在进行中。主要是长期接触多氯二苯并呋喃对健康的影响将通过后续行动得到澄清。
A national survey of polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) in emission gases from the municipal waste incinerators in 1997 revealed that the Nose Bika Center was heavily contaminated by PCDF. Ninety-four workers underwent a physical examination, and blood biochemistry, lymphocyte marker, and NK activity studies were carried out, along with blood dioxin measurements. Information on working history, life-style, and dietary habits was obtained by questionnaire and interview. The blood dioxin levels were as follows. The median TEQ of dioxins was 39.7 pg I-TEQ/g lipid, and the range was 13.3 to 805.8. The median 2,3,7,8-TCDD concentration was 3.9 pg TEQ/g lipid, and the range was <1 pg TEQ/g lipid (one case) to 13.4 pg TEQ/g lipid. The median TEQ of coplanar PCB was 10.8 pg I-TEQ/g lipid, and the range was 3.1 to 54.2 pg TEQ/g lipid. The congener-specific distribution was quite similar to that in soil around incinerator and waste in the factory. The relationship between dioxin concentrations and work history in the factory showed that the fluidized incinerator and fly ash treatment areas were high-risk work areas. Correlation analyses between body burden, PCDD/PCDF TEQ, Co-PCB TEQ and various laboratory data showed significant positive correlations between dioxin levels and GGT, total protein, uric acid and calcium, and a negative correlation with Fe. However, these correlations disappeared as a result of multivariate analysis adjusted for age, smoking status, and alcohol drinking. Increased NK activity and lower response to PHA stimulation remained significant even after adjusting for age. History of hyperlipidemia and allergy had significantly increased odds ratios. A study on the risk to other workers in the same type of incinerators is under way. Health effects of chronic exposure mainly to PCDF will be clarified by follow-up.