THE EFFECT OF INCREASING THE TREATMENT TIME BEYOND 3 WEEKS ON THE CONTROL OF T2 AND T3 LARYNGEAL-CANCER USING RADIOTHERAPY
THE EFFECT OF INCREASING THE TREATMENT TIME BEYOND 3 WEEKS ON THE CONTROL OF T2 AND T3 LARYNGEAL-CANCER USING RADIOTHERAPY
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DOI：
10.1016/0167-8140(92)90226-k
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发表时间：
1992-08-01
影响因子：
5.7
通讯作者：
AGRENCRONQVIST, A
中科院分区：
文献类型：
--
作者：
SLEVIN, NJ;HENDRY, JH;AGRENCRONQVIST, A
放疗对局部癌症的控制可能会因肿瘤克隆原的加速重新聚集而受到影响，特别是在延长治疗计划期间。我们研究了496例接受放疗治疗的T2和T3喉癌患者，研究了9 - 41天的治疗时间对局部控制的影响。使用描述分馏灵敏度的线性二次公式分析数据，并纳入与处理时间相关的参数。结合T2和T3数据，维持恒定的局部控制（时间因子）所需的剂量增加在每天0.5至0.6 Gy之间。这些数值与文献中报道的4周或更长时间的数值相似。此外，在21天的标准Christie持续时间内，计算出的控制50%肿瘤的剂量与从28-66天的文献数据中推算出来的剂量一致。目前的数据与在放疗开始后不超过3周的滞后期存在这样一个时间因素是一致的。因此，应进一步考虑在头颈癌放疗中使用更短的总治疗时间。
Local control of cancer by radiotherapy may be prejudiced by accelerated tumour clonogen repopulation particularly during protracted treatment schedules. A series of 496 cases of T2 and T3 larynx cancer treated here by radiotherapy has been studied to examine the impact on local control of treatment durations ranging from 9 to 41 days. Data were analysed using a linear-quadratic formulation describing the fractionation sensitivity, with the incorporation of a parameter relating to treatment time. Using combined T2 and T3 data, the increase in dose required to maintain a constant local control (the time factor) was between 0.5 and 0.6 Gy per day. These values are similar to those reported for 4 weeks or more in the literature. Also, the calculated dose to control 50% of tumours, given over the standard Christie duration of 21 days, was on the line projected back from literature data over 28-66 days. The present data are consistent with the presence of such a time factor following a lag phase of not more than 3 weeks after starting radiotherapy. Hence, further consideration should be given to using shorter overall treatment times in radiotherapy for head and neck cancer.