Single acquisition quantitative single-point electron paramagnetic resonance imaging.
Single acquisition quantitative single-point electron paramagnetic resonance imaging.
复制标题
单一采集定量单点电子顺磁共振成像。
DOI：
10.1002/mrm.24886
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发表时间：
2013-10
影响因子：
3.3
通讯作者：
McMillan, Alan B.
中科院分区：
文献类型：
--
作者：
Jang, Hyungseok;Subramanian, Sankaran;Devasahayam, Nallathamby;Saito, Keita;Matsumoto, Shingo;Krishna, Murali C.;McMillan, Alan B.
电子顺磁共振成像（EPRI）已成为一种有前途的无创组织氧动态成像技术。由于其极短的自旋-自旋弛豫时间，EPRI受益于单点成像（SPI）方案，其中使用纯相位编码捕获整个FID信号。然而，由于恒定的幅度梯度导致视场时间减小，直接定量T2*/pO2受到抑制。因此，传统的采集技术需要进行不同梯度幅值（通常为3）的重复成像实验，导致采集时间长。在本研究中，我们评估了网格划分作为一种重建等视场图像的方法，以实现在单次成像实验中直接量化T2*/pO2。此外，研究了一种增强的重建技术，该技术在不同的相位编码时间延迟中共享高空间k空间区域（k空间外推）。网格化和k空间外推的结合应用使T2*的像素量化能够从单次采集中获得，并在广泛的相位编码延迟时间范围内提高图像质量。计算出的T2*/pO2在此时间范围内不变化。通过利用网格和k空间外推，可以在单个数据集内实现精确的T2*/pO2量化，从而提高时间分辨率（提高3倍）。
Electron paramagnetic resonance imaging (EPRI) has emerged as a promising non-invasive technology to dynamically image tissue oxygenation. Due to its extremely short spin-spin relaxation times, EPRI benefits from a single-point imaging (SPI) scheme where the entire FID signal is captured using pure phase encoding. However, direct T2*/pO2 quantification is inhibited due to constant magnitude gradients which result in time-decreasing FOV. Therefore, conventional acquisition techniques require repeated imaging experiments with differing gradient amplitudes (typically 3), which results in long acquisition time. In this study, gridding was evaluated as a method to reconstruct images with equal FOV to enable direct T2*/pO2 quantification within a single imaging experiment. Additionally, an enhanced reconstruction technique that shares high spatial k-space regions throughout different phase encoding time delays was investigated (k-space extrapolation). The combined application of gridding and k-space extrapolation enables pixelwise quantification of T2* from a single acquisition with improved image quality across a wide range of phase encoding delay times. The calculated T2*/pO2 does not vary across this time range. By utilizing gridding and k-space extrapolation, accurate T2*/pO2 quantification can be achieved within a single dataset to allow enhanced temporal resolution (by a factor of 3).
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影响因子：
2.2
作者：
Luo, Jianhua;Wang, Shanshan;Zhu, Yuemin
通讯作者：
Zhu, Yuemin
影响因子：
3.3
作者：
Matsumoto, K;Subramanian, S;Krishna, MC
通讯作者：
Krishna, MC
影响因子：
2.6
作者：
BROWN, JM
通讯作者：
BROWN, JM
影响因子：
3.3
作者：
Haupt, CI;Schuff, N;Maudsley, AA
通讯作者：
Maudsley, AA
DOI：
10.1002/jmri.1880010309
发表时间：
1991-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
AMARTUR, S;HAACKE, EM
通讯作者：
HAACKE, EM