Transition-Metal-Free Intermolecular Amination of sp3 C-H Bonds with Sulfonamides
Transition-Metal-Free Intermolecular Amination of sp3 C-H Bonds with Sulfonamides
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DOI：
10.1021/ol900090f
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发表时间：
2009-03-19
期刊：
影响因子：
5.2
通讯作者：
Zhang, Li
中科院分区：
文献类型：
--
作者：
Fan, Renhua;Li, Weixun;Zhang, Li
描述了一种有效的无过渡金属的磺胺类分子间苯酰胺化反应。各种有价值的含氮化合物，包括胺、-氯胺、氨基醇、-、-氨基酯和n-磺酰基亚胺，都是由饱和苯基C-H键的优先n功能化产生的。该反应体系的潜力还在于它可以发展成为一种环境友好的分子间酰胺化过程。
An efficient transition-metal-free intermolecular benzylic amidation with sulfonamides is described. Various valuable nitrogen-containing compounds, including amines, beta-chloro amine, amino alcohol, alpha-, beta-amino ester, and N-sulfonyl imine, are generated from the preferential N-functionalization of saturated benzylic C-H bonds. The potential of this reaction system also lies in the fact it can be developed into an environmentally friendly intermolecular amidation process.