RNA-based gene duplication: mechanistic and evolutionary insights.
RNA-based gene duplication: mechanistic and evolutionary insights.
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DOI：
10.1038/nrg2487
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发表时间：
2009-01
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源自亲本源基因mRNA的基因拷贝长期以来被视为进化的死胡同，几乎没有生物学相关性。在此，我们回顾了一系列近期的研究，这些研究揭示了在哺乳动物以及一些非哺乳动物基因组（特别是果蝇的基因组）中存在大量有功能的反转录基因拷贝。这些研究不仅揭示了新基因及其功能出现的先前未知的机制，还为塑造基因组的分子和进化过程提供了引人入胜的一般性见解。例如，通过基于RNA的基因复制对染色体基因移动模式的分析，为我们性染色体的进化起源和生物学提供了全新的视角。
Gene copies that stem from the mRNAs of parental source genes have long been viewed as evolutionary dead-ends with little biological relevance. Here we review a range of recent studies that have unveiled a significant number of functional retroposed gene copies in both mammalian but also some non-mammalian genomes (in particular that of the fruitfly). These studies not only revealed previously unknown mechanisms for the emergence of new genes and their functions but also provided fascinating general insights into molecular and evolutionary processes that have shaped genomes. For example, analyses of chromosomal gene movement patterns via RNA-based gene duplication have shed fresh new light on the evolutionary origin and biology of our sex chromosomes.