Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption
Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption
复制标题
DOI：
10.1093/oxfordjournals.aje.a010183
复制
发表时间：
2000-01-15
影响因子：
5
通讯作者：
Matkin, C
中科院分区：
文献类型：
--
作者：
Nelson, LM;McGuire, V;Matkin, C
1990 年至 1994 年，在华盛顿州西部的三个县进行了一项基于人群的病例对照研究，调查了吸烟和饮酒与肌萎缩侧索硬化症 (ALS) 风险之间的关系。确定了 ALS 事件病例 (n = 161)，并将其与通过随机数字拨号和医疗保险登记文件确定的人口对照 (n = 321) 进行匹配。使用条件逻辑回归分析来计算根据年龄、性别、受访者类型和教育程度进行调整的比值比。作者发现饮酒与 ALS 风险无关。曾经吸过烟与风险增加两倍相关（酒精调整比值比 (OR)= 2.0，95% 置信区间 (Cl)：1.3、3.2）。目前吸烟者的风险增加了三倍以上（酒精调整 OR = 3.5，95% CI：1.9，6.4），而以前吸烟者的风险仅适度增加（酒精调整 OR = 1.5，95% CI：0.9，2.4）。吸烟持续时间（趋势 p = 0.001）和香烟包年数（趋势 p = 0.001）观察到 ALS 风险的显着趋势。吸烟是 ALS 危险因素的发现与当前的病因学理论一致，即环境化学物质和氧化应激与 ALS 发病机制有关。
The associations of cigarette smoking and alcohol consumption with the risk of amyotrophic lateral sclerosis (ALS) were investigated in a population-based case-control study conducted in three counties of western Washington State from 1990 to 1994. Incident ALS cases (n = 161) were identified and were matched to population controls (n = 321) identified through random digit dialing and Medicare enrollment files. Conditional logistic regression analysis was used to compute odds ratios adjusted for age, gender, respondent type, and education. The authors found that alcohol consumption was not associated with the risk of ALS. Ever having smoked cigarettes was associated with a twofold increase in risk (alcohol-adjusted odds ratio (OR)= 2,0, 95% confidence interval (Cl): 1.3, 3.2). A greater than threefold increased risk was observed for current smokers (alcohol-adjusted OR = 3.5, 95% Ct: 1.9, 6.4), with only a modestly increased risk for former smokers (alcohol-adjusted OR = 1.5, 95% CI: 0.9, 2.4). Significant trends in the risk of ALS were observed with duration of smoking (p for trend = 0.001) and number of cigarette pack-years (p for trend = 0.001),The finding that cigarette smoking is a risk factor for ALS is consistent with current etiologic theories that implicate environmental chemicals and oxidative stress in the pathogenesis of ALS.