Water loss and defects dependent strength and ductility of articular cartilage
Water loss and defects dependent strength and ductility of articular cartilage
复制标题
失水和缺陷取决于关节软骨的强度和延展性
DOI：
10.1016/j.jmrt.2022.10.024
复制
发表时间：
2022-10-20
影响因子：
6.4
通讯作者：
Ren，Luquan
中科院分区：
文献类型：
--
作者：
Liu，Jize;Xu，Shuting;Ren，Luquan
关节软骨的水分流失和表面缺损极大地增加了骨关节疾病的风险。含水量和表面缺陷对软骨力学性能的影响需要进一步考虑。利用自行研制的原位拉伸试验机，获得了不同含水量条件下，有无微孔洞时的拉伸应力-应变关系和实时形态变化。证实了组织结构和渗透性是影响软骨强度和延展性的主要因素。含水量越少，渗透率越低，强度越高，塑性越差。拉曼光谱分析结果直接揭示了干燥处理和拉伸变形均导致软骨层中氢键较强的结合水向氢键较弱的自由水转变，导致渗透性降低，抗变形能力增强。拉曼基有机基质含量与渗透性呈负相关，但与软骨强度呈正相关。所得实验数据有助于预测软骨损伤和开发人工软骨材料。
Water loss and surface defects of articular cartilage extremely aggravate the risk of osteoarticular diseases. The effects of water content and surface defects on the mechanical properties of cartilage need to be taken into further account. By using a self-developed in-situ tensile tester, the tensile stress-strain relationship and real-time morphological changes under conditions of different water contents are obtained with and without a micro void. It is confirmed that tissue structure and permeability are the main factors affecting the strength and ductility of cartilage. The less water content contributes to the lower permeability, inducing higher strength but poorer plasticity. Raman spectroscopy analysis results directly reveal the transition from the bonding water with stronger hydrogen bonds to the free water with weaker hydrogen bonds in cartilage layer caused by both drying treatment and tensile deformation, which results in decreased permeability and enhanced resistance to deformation. Raman-based organic matrix content is negatively correlated with permeability but positively correlated with the strength of cartilage. The obtained experimental data may facilitate to predict cartilage damage and develop artificial cartilage materials.