L-DOPA IS CONVERTED TO DOPAMINE IN SEROTONERGIC FIBERS OF THE STRIATUM OF THE RAT - A DOUBLE-LABELING IMMUNOFLUORESCENCE STUDY
L-DOPA IS CONVERTED TO DOPAMINE IN SEROTONERGIC FIBERS OF THE STRIATUM OF THE RAT - A DOUBLE-LABELING IMMUNOFLUORESCENCE STUDY
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DOI：
10.1016/0304-3940(95)11817-g
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发表时间：
1995-08-11
影响因子：
2.5
通讯作者：
NAGATSU, I
中科院分区：
文献类型：
--
作者：
ARAI, R;KARASAWA, N;NAGATSU, I
本研究的目的是检查是否多巴胺能末梢的大鼠脑诱导含有左旋多巴管理。在接受腹腔注射L-DOPA加外周脱羧酶抑制剂的大鼠中，我们通过使用双标记免疫荧光方法表明，多巴胺定位于纹状体和大脑皮质的多巴胺能纤维以及中脑中缝核的多巴胺能细胞体。在正常大鼠中，在多巴胺能纤维或细胞体中未检测到多巴胺。这一发现表明，给予的L-DOPA的一部分可能进入多巴胺能末梢，并在大鼠脑中转化为多巴胺。
The aim of the present study is to examine whether serotonergic terminals of the rat brain are induced to contain dopamine by L-DOPA administration. In rats that received intraperitoneally L-DOPA plus a peripheral decarboxylase inhibitor, we showed by use of a double-labeling immunofluorescence method that dopamine was localized in serotonergic fibers of the striatum and cerebral cortex as well as in serotonergic cell bodies of the midbrain raphe nuclei. In normal rats, no dopamine was detected in the serotonergic fibers or cell bodies. The finding suggests that a part of the administered L-DOPA may enter the serotonergic terminals and be converted to dopamine in the rat brain.