Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury
Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury
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DOI：
10.1093/brain/awz290
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发表时间：
2019-11-01
期刊：
影响因子：
14.5
通讯作者：
Latour, Lawrence L.
中科院分区：
文献类型：
--
作者：
Griffin, Allison D.;Turtzo, L. Christine;Latour, Lawrence L.
创伤性微出血是在头部创伤后患者的T-2* 加权MRI上看到的低信号小病灶，以前被认为是轴突损伤的标志。一些创伤性微出血的线性外观和位置提示血管起源。本研究的目的是：（i）确定和表征急性创伤性脑损伤患者的创伤性微出血;（ii）确定创伤性微出血的出现是否可预测临床结局;（iii）描述索引患者创伤性微出血的病理学基础。急性头部创伤后到急诊科接受头部CT的患者在受伤后48小时内入组，并接受研究MRI。残疾的定义采用格拉斯哥结局量表-扩展
Traumatic microbleeds are small foci of hypointensity seen on T-2*-weighted MRI in patients following head trauma that have previously been considered a marker of axonal injury. The linear appearance and location of some traumatic microbleeds suggests a vascular origin. The aims of this study were to: (i) identify and characterize traumatic microbleeds in patients with acute traumatic brain injury; (ii) determine whether appearance of traumatic microbleeds predict clinical outcome; and (iii) describe the pathology underlying traumatic microbleeds in an index patient. Patients presenting to the emergency department following acute head trauma who received a head CT were enrolled within 48 h of injury and received a research MRI. Disability was defined using Glasgow Outcome Scale-Extended