Molecular Biology of Endometriosis
Molecular Biology of Endometriosis
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DOI：
10.1002/9781118849613.ch3
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发表时间：
2016-12
期刊：
影响因子：
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通讯作者：
J. Sengupta;G. Anupa;Muzaffer Ahmed Bhat;D. Ghosh
中科院分区：
文献类型：
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作者：
J. Sengupta;G. Anupa;Muzaffer Ahmed Bhat;D. Ghosh
子宫内膜异位症是一种常见的妇科疾病，通常表现为不孕和盆腔疼痛。已经确定了三种不同表型的子宫内膜异位症：腹膜子宫内膜异位症、卵巢子宫内膜异位症（或子宫内膜异位症）和直肠阴道子宫内膜异位症病变。这三种不同类型的疾病的确切病理生理基础尚不清楚。在这篇综述中，我们试图分析最近的基因组学和蛋白质组学数据，为子宫内膜异位症的分子基础提出一些新的线索。此外，我们强调了子宫内膜异位症新积累的知识的一些重要的翻译意义。
Endometriosis is a common gynaecological disorder that often presents with infertility and pelvic pain. Three different phenotypes of endometriosis disease have been identified: peritoneal endometriosis, ovarian endometriosis (or endometrioma), and rectovaginal endometriotic lesions. The precise pathophysiological basis of these three different types of the disorder is not clear. In the present review chapter, we make an attempt to analyze recent genomics and proteomics data to put forward some novel leads regarding the molecular basis of endometriosis. Further, we highlight a few important translational implications of the newly accrued knowledge on endometriosis.